GEMIN8

  • Official Full Name

    gem (nuclear organelle) associated protein 8

  • Overview

    The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.

  • Synonyms

    GEMIN8;gem (nuclear organelle) associated protein 8;FAM51A1, family with sequence similarity 51, member A1;gem-associated protein 8;FLJ20514;gemin-8;family with sequence similarity 51, member A1;FAM51A1;FLJ43072

Recombinant Proteins

  • Human
  • Zebrafish
  • Rhesus macaque
  • Mouse
  • E.coli
  • Mammalian Cell
  • HEK293
  • HEK293T
  • Wheat Germ
  • In Vitro Cell Free System
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
GEMIN8-13226H Recombinant Human GEMIN8, His-tagged E.coli Human His 1-242a.a.
GEMIN8-1709Z Recombinant Zebrafish GEMIN8 Mammalian Cell Zebrafish His
GEMIN8-1830R Recombinant Rhesus monkey GEMIN8 Protein, His-tagged Mammalian Cell Rhesus macaque His
GEMIN8-6304M Recombinant Mouse GEMIN8 Protein Mammalian Cell Mouse His
GEMIN8-5958HCL Recombinant Human GEMIN8 293 Cell Lysate HEK293 Human Non
GEMIN8-1651R Recombinant Rhesus Macaque GEMIN8 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
GEMIN8-1651R-B Recombinant Rhesus Macaque GEMIN8 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
GEMIN8-3028H Recombinant Human GEMIN8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
Gemin8-3190M Recombinant Mouse Gemin8 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
GEMIN8-3532M Recombinant Mouse GEMIN8 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
GEMIN8-3532M-B Recombinant Mouse GEMIN8 Protein Pre-coupled Magnetic Beads HEK293 Mouse
GEMIN8-4845H Recombinant Human GEMIN8 Protein, GST-tagged Wheat Germ Human GST
GEMIN8-5313HF Recombinant Full Length Human GEMIN8 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 242 amino acids
GEMIN8-5583H Recombinant Human GEMIN8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK

    Involved Pathway

    GEMIN8 involved in several pathways and played different roles in them. We selected most pathways GEMIN8 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with GEMIN8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RNA transport ELAC1,POP7,NXF2,FXR1,EIF4EA,NUP160,EIF3BA,EEF1A2,NUP153,NUP205

    Protein Function

    GEMIN8 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GEMIN8 itself. We selected most functions GEMIN8 had, and list some proteins which have the same functions with GEMIN8. You can find most of the proteins on our site.

    Function Related Protein
    protein binding KRAS,CXCL14,PSMB3,PAK3,POLM,GSPT2,MGAT5B,CCL28,MARCKSL1,GDNF

    Interacting Protein

    GEMIN8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GEMIN8 here. Most of them are supplied by our site. Hope this information will be useful for your research of GEMIN8.

    LRRK2;Smn1;SMN1;Snrnp70;GEMIN5;GEMIN7

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