GEMIN5

  • Official Full Name

    gem (nuclear organelle) associated protein 5

  • Overview

    This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

  • Synonyms

    GEMIN5;gem (nuclear organelle) associated protein 5;GEMIN-5;gem-associated protein 5

Recombinant Proteins

  • Human
  • Mouse
  • HEK293
  • HEK293T
  • Mammalian cells
  • Wheat Germ
  • Myc&DDK
  • Flag
  • GST
  • His&Fc&Avi

    Involved Pathway

    GEMIN5 involved in several pathways and played different roles in them. We selected most pathways GEMIN5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GEMIN5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    GEMIN5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by GEMIN5 itself. We selected most functions GEMIN5 had, and list some proteins which have the same functions with GEMIN5. You can find most of the proteins on our site.

    Function Related Protein

    Interacting Protein

    GEMIN5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GEMIN5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GEMIN5.

    Resources

    References

    • Fernandez-Chamorro, J; Pineiro, D; et al. Identification of novel non-canonical RNA-binding sites in Gemin5 involved in internal initiation of translation. NUCLEIC ACIDS RESEARCH 42:5742-5754(2014).
    • Borg, R; Cauchi, RJ; et al. The Gemin Associates of Survival Motor Neuron Are Required for Motor Function in Drosophila. PLOS ONE 8:-(2013).

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