GCNT3
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Official Full Name
glucosaminyl (N-acetyl) transferase 3, mucin type -
Overview
This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins. -
Synonyms
GCNT3;glucosaminyl (N-acetyl) transferase 3, mucin type;beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3;C2/4GnT;C2GnT M;C2GnT2;hC2GnT-M;C2GnT-mucin type;beta1,6GlcNAc-transferase;beta1,6-N-acetylglucosaminyl
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
GCNT3 involved in several pathways and played different roles in them. We selected most pathways GCNT3 participated on our site, such as Metabolic pathways,Metabolism of proteins,Mucin type O-Glycan biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCNT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mucin core 1 and core 2 O-glycosylation | GALNTL2,GALNT13,GALNT6,GALNT5 |
| O-linked glycosylation of mucins | GALNTL2,KCNA6,MUC4,GALNT13,GALNTL5,B3GNT6,A4GNT,MUC20,MUC12,MUC1 |
| Mucin type O-Glycan biosynthesis | ST6GALNAC1,GALNT10,GALNT1,GCNT1,C1GALT1,GALNTL4,GCNT4A,B3GNT6,GCNT4,GALNT12 |
| Post-translational protein modification | TRAPPC4,MUC21,YKT6,NSMCE1,GNE,ARSF,ARSD,TRAPPC6B,CTAGE5,ARSH |
| Metabolism of proteins | GNE,SEC61B,ALG2,SPON1,TFG,EIF4H,COX17,MUC4,TIMM17A,PPP6R3 |
| O-linked glycosylation | MUC5AC,B3GNT6,KCNA6,GALNT5,A4GNT,MUC4,ADAMTS18,B3GNT8,THSD7A,MUC21 |
| terminal O-glycans residues modification | FUT9 |
| Metabolic pathways | MTR,HSD3B7,ALDH6A1,P4HA2,SDHDA,ATP5I,OTC,TPH1,NAGK,GANC |
Protein Function
GCNT3 has several biochemical functions, for example, N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity,acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity,beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GCNT3 itself. We selected most functions GCNT3 had, and list some proteins which have the same functions with GCNT3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity | GCNT4,GCNT2 |
| beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity | GCNT4A,GCNT1,GCNT4 |
Interacting Protein
GCNT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCNT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GCNT3.
CASK;SNUPN;DHRSX;RBM18
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References
- Gonzalez-Vallinas, M; Vargas, T; et al. Clinical relevance of the differential expression of the glycosyltransferase gene GCNT3 in colon cancer. EUROPEAN JOURNAL OF CANCER 51:1-8(2015).
- Petrosyan, A; Holzapfel, MS; et al. Restoration of Compact Golgi Morphology in Advanced Prostate Cancer Enhances Susceptibility to Galectin-1-Induced Apoptosis by Modifying Mucin O-Glycan Synthesis. MOLECULAR CANCER RESEARCH 12:1704-1716(2014).
