GCN5
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Official Full Name
Gcn5p -
Overview
SAGA (Spt-Ada-Gen5 histone acetyltransferase complex) is a histoneacetylase complex which has Gcn5p as catalyst subunit and functions overlapping with the fundamental transcription factor TFIID which has Taf1p as catalyst subunit. However, SAGA and TFIID have different allotment and each accomplishes the important role in the transcription for Housekeeping gene group and Stress Responding gene group. Also, SAGA is a gigantic protein complex which is composed of Ada protein group (5 kinds), TBP related protein group (4 kinds), TAF protein group (5 kinds that also pertain to TFIID), and other protein groups (>6 kinds). As its molecular function, there is the chemical modification of histone, or the recruitment by direct interaction of transcription regulating factor on DNA, or the control of transcription starting reaction by TBP. Gcn5p that show histoneacetylase activity is one kind of the above-mentioned Ada protein group and in the case of budding yeast it is composed of 439 amino acid recidues (aa). The product is prepared by immunizing rabbit with recombinant protein which was over-expressed in E. coli with a plasmid carrying the N terminal domain (1-300aa) of Gcn5p protein which is coded on the GCN5 gene of budding yeast, and purified by chromatography. Using the product as antiserum in Western blotting, the band of 54 kD pertaining to Gcn5p was obtained from the extract solution of budding cells. -
Synonyms
GCN5;Gcn5p;AAS104;YGR252W;ADA4;SWI9;NP_011768.1;EC 2.3.1.48;Eukaryota;Fungi;Ascomycota;Saccharomycotina (true yeasts);Taphrinomycotina;Schizosaccharomycetes (fission yeasts);Basidiomycota;Agaricomycotina;Tremellomycetes;Pucciniomycotina;Microbotryomycetes
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Kit-1736 | GCN5 Chemiluminescent Assay Kit | Non |
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Involved Pathway
GCN5 involved in several pathways and played different roles in them. We selected most pathways GCN5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GCN5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
GCN5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by GCN5 itself. We selected most functions GCN5 had, and list some proteins which have the same functions with GCN5. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
GCN5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCN5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GCN5.
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References
- Chen, W; Xiong, S; et al. The Ubiquitin E3 Ligase SCF-FBXO24 Recognizes Deacetylated Nucleoside Diphosphate Kinase A To Enhance Its Degradation. MOLECULAR AND CELLULAR BIOLOGY 35:1001-1013(2015).
- Picazo, C; Orozco, H; et al. Interplay among Gcn5, Sch9 and Mitochondria during Chronological Aging of Wine Yeast Is Dependent on Growth Conditions. PLOS ONE 10:-(2015).
