GCM2
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Official Full Name
glial cells missing homolog 2 (Drosophila) -
Overview
Gcm2, a mouse ortholog of the Drosophila Glial Cells Missing gene, is expressed in the parathyroid-specific domains in the 3rd pouches from E9.5. The null mutation of Gcm2 causes aparathyroidism in the fetal and adult mouse and has been proposed to be a master regulator for parathyroid development. During Drosophila embryogenesis Gcm2 plays a crucial role in promoting glial cell differentiation. -
Synonyms
GCM2;glial cells missing homolog 2 (Drosophila);chorion-specific transcription factor GCMb
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GCM2-1442Z | Recombinant Zebrafish GCM2 | Mammalian Cells | Zebrafish | His |
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| GCM2-1858C | Recombinant Chicken GCM2 | Mammalian Cells | Chicken | His |
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| GCM2-6269M | Recombinant Mouse GCM2 Protein | Mammalian Cells | Mouse | His |
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| GCM2-3510M | Recombinant Mouse GCM2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GCM2-3510M-B | Recombinant Mouse GCM2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
GCM2 involved in several pathways and played different roles in them. We selected most pathways GCM2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GCM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
GCM2 has several biochemical functions, for example, DNA binding,metal ion binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GCM2 itself. We selected most functions GCM2 had, and list some proteins which have the same functions with GCM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | HIST1H2AL,MNDA,ONECUT3,CHES1,ABI2,FOXE1,UHRF2,KDM2AA,FOXA2,MEF2C |
| transcription factor activity, sequence-specific DNA binding | KAT7,POU4F3,ZBTB11,HOXB4,SLC25A46,ZNF480,MSC,ZNF621,CTCF,NFAT5 |
| metal ion binding | PLA2G4AA,PLA2G3,HINFP,KCNIP3A,RORCA,ITGAL,ARSK,Car9,CYP46A1.4,ZFP541 |
| sequence-specific DNA binding | LHX6,HOXC12A,CTCFL,ESRRGA,SALL3,NR2F5,HLFA,FLI1A,CEBPG,SPIC |
Interacting Protein
GCM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GCM2.
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References
- D'Agruma, L; Coco, M; et al. Increased Prevalence of the GCM2 Polymorphism, Y282D, in Primary Hyperparathyroidism: Analysis of Three Italian Cohorts. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:E2794-E2798(2014).
- Mitsui, T; Narumi, S; et al. Comprehensive Next-Generation Sequencing Analyses of Hypoparathyroidism: Identification of Novel GCM2 Mutations. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:E2421-E2428(2014).
