GCAT
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Official Full Name
glycine C-acetyltransferase -
Overview
The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14. -
Synonyms
GCAT;glycine C-acetyltransferase;glycine C acetyltransferase (2 amino 3 ketobutyrate coenzyme A ligase);2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial;2 amino 3 ketobutyrate coenzyme A ligase;KBL;AKB ligase;aminoacetone synthase;glycine a
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GCAT-313H | Recombinant Human GCAT Protein, His-tagged | E.coli | Human | His |
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| GCAT-567H | Recombinant Human glycine C-acetyltransferase, His-tagged | E.coli | Human | His | 22-419 a.a. |
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| GCAT-7684Z | Recombinant Zebrafish GCAT | Mammalian Cell | Zebrafish | His |
|
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| GCAT-5993HCL | Recombinant Human GCAT 293 Cell Lysate | HEK293 | Human | Non |
|
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| Gcat-1569M | Recombinant Mouse Gcat Protein, His-tagged | E.coli | Mouse | His | Gly59-Phe226 |
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| Gcat-1570R | Recombinant Rat Gcat Protein, His-tagged | E.coli | Rat | His | Tyr221-Pro416 |
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| GCAT-2195H | Recombinant Human GCAT Protein, His-tagged | E.coli | Human | His | Tyr224-Cys404 |
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| GCAT-4788H | Recombinant Human GCAT Protein, GST-tagged | Wheat Germ | Human | GST |
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| GCAT-5165HF | Recombinant Full Length Human GCAT Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 419 amino acids |
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Involved Pathway
GCAT involved in several pathways and played different roles in them. We selected most pathways GCAT participated on our site, such as Glycine, serine and threonine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycine, serine and threonine metabolism | GATM,DAO1,ALAS1,AGXT2,AGXTB,SRR,GRHPRB,CBS,GCSHB,PGAM1A |
Protein Function
GCAT has several biochemical functions, for example, glycine C-acetyltransferase activity,pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GCAT itself. We selected most functions GCAT had, and list some proteins which have the same functions with GCAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| pyridoxal phosphate binding | SPTLC2,SHMT2,PDXK,CSAD,CCBL1,KYNU,GOT2,MARC1,ACCS,ALAS2 |
Interacting Protein
GCAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCAT here. Most of them are supplied by our site. Hope this information will be useful for your research of GCAT.
TEAD1;MDM2;ECSIT
Resources
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References
- Tan, N; Yu, LQ; et al. Kinetics of the propylene polymerization with prepolymerization at high temperature using Ziegler-Natta catalyst. JOURNAL OF APPLIED POLYMER SCIENCE 132:-(2015).
- Highnam, G; Wang, JJ; et al. An analytical framework for optimizing variant discovery from personal genomes. NATURE COMMUNICATIONS 6:-(2015).
