GBF1
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Official Full Name
golgi brefeldin A resistant guanine nucleotide exchange factor 1 -
Overview
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the GBF1 gene. -
Synonyms
GBF1;golgi brefeldin A resistant guanine nucleotide exchange factor 1;Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1;BFA-resistant GEF 1;ARF1GEF;KIAA0248;golgi-specific brefeldin A resistance factor 1;FLJ21500;MGC134877;MGC134878;OTTHUMP00000020365
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GBF1-654H | Recombinant Human GBF1 | Mammalian Cell | Human | His |
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| GBF1-3019H | Recombinant Human GBF1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| GBF1-3019H-B | Recombinant Human GBF1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| GBF1-4773H | Recombinant Human GBF1 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
GBF1 involved in several pathways and played different roles in them. We selected most pathways GBF1 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GBF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | SH3GLB2A,VPS28,SH3GLB1B,EHD4,CAPZA1,VPS4A,STAMBPB,HSC70,WIPF2B,PSD3 |
Protein Function
GBF1 has several biochemical functions, for example, ARF guanyl-nucleotide exchange factor activity,phosphatidylinositol-3,4,5-trisphosphate binding,phosphatidylinositol-3,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GBF1 itself. We selected most functions GBF1 had, and list some proteins which have the same functions with GBF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FAM20A,CP110,CCND3,MAP3K11,CAML,GIMAP7,HRAS,DHX38,PEX5,COMMD1 |
| ARF guanyl-nucleotide exchange factor activity | CYTH3,ARFGEF2,CYTH1B,PSD3,FBXO8,IQSEC1,CYTH4,PSD2,MON2,PSD4 |
| phosphatidylinositol-3,4,5-trisphosphate binding | MYO1G,ARAP1,FAM21C,BTK,ANXA8,CYTH3,KIF16B,DAPP1,OGT,RS1 |
| phosphatidylinositol-3,5-bisphosphate binding | SNX3,WDR45B,FAM21C,JPH2,SH3PXD2B,WIPI1,WDR45,MAPKAP1,PHLDA3,RAG2 |
Interacting Protein
GBF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GBF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GBF1.
YWHAG;YWHAB;PTP4A3;TNFRSF1B;COPB1;COPG1;KBTBD7;COPG1;wcaG6;pi3p;IRS4;ZSCAN26;Ccser2;FBXO7;USO1
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References
- Arst, HN; Hernandez-Gonzalez, M; et al. GBF/Gea mutant with a single substitution sustains fungal growth in the absence of BIG/Sec7. FEBS LETTERS 588:4799-4806(2014).
- Dorobantu, CM; Ford-Siltz, LA; et al. GBF1-and ACBD3-Independent Recruitment of PI4KIII beta to Replication Sites by Rhinovirus 3A Proteins. JOURNAL OF VIROLOGY 89:1913-1918(2015).
