GBA3
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Official Full Name
glucosidase, beta, acid 3 (cytosolic) -
Overview
GBA3, or cytosolic beta-glucosidase (EC 3.2.1.21), is a predominantly liver enzyme that efficiently hydrolyzes;beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be;involved in detoxification of plant glycosides (de Graaf et al., 2001 (PubMed 11389701)). GBA3 also has significant;neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a nonlysosomal catabolic;pathway of glucosylceramide metabolism (Hayashi et al., 2007 (PubMed 17595169)). -
Synonyms
GBA3;glucosidase, beta, acid 3 (cytosolic);cytosolic beta-glucosidase;GLUC;klotho related protein;KLrP;CBG;CBGL1;Cytosolic beta glucosidase;Cytosolic beta glucosidase like protein 1;Cytosolic beta-glucosidase-like protein 1;GBA3_HUMAN;Glucosidase beta acid 3;klotho-related protein
Recombinant Proteins
- Human
- Zebrafish
- E.coli
- Insect Cell
- Insect Cells
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GBA3-13175H | Recombinant Human GBA3, His-tagged | E.coli | Human | His | 1-162a.a. | |
| GBA3-856H | Recombinant Human GBA3, His tagged | Insect Cell | Human | His | 1-469 a.a. | |
| GBA3-174H |
Active Recombinant Human GBA3 protein, His-tagged
|
Insect Cells | Human | His | Met1-Leu469 |
|
| GBA3-2855Z | Recombinant Zebrafish GBA3 | Mammalian Cell | Zebrafish | His |
|
|
| GBA3-626H | Recombinant Human glucosidase, beta, acid 3, His-tagged | E.coli | Human | His | 1-469 a.a. |
|
| GBA3-661HCL | Recombinant Human GBA3 cell lysate | Insect Cell | Human | Non |
|
|
| GBA3-1327H | Recombinant Human GBA3 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
|
|
| GBA3-2577H | Recombinant Human GBA3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
|
|
| GBA3-4768H | Recombinant Human GBA3 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| GBA3-4900H | Recombinant Human GBA3 protein, GST-tagged | E.coli | Human | GST | 1-162aa |
|
| GBA3-5518HF | Recombinant Full Length Human GBA3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 469 amino acids |
|
Involved Pathway
GBA3 involved in several pathways and played different roles in them. We selected most pathways GBA3 participated on our site, such as Cyanoamino acid metabolism,Starch and sucrose metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GBA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cyanoamino acid metabolism | GGT7,GGT5,SHMT1,GGT6,GGT5A,GGT1,GGT1A,SHMT2 |
| Metabolic pathways | AGXTA,DGAT1A,ACSBG2,UROD,COX6B2,HIBADHB,ENO3,PGD,PPAP2B,HSD3B1 |
| Starch and sucrose metabolism | UGT1AB,GPI1,AMY1B,G6PC,AMY1A,UXS1,PYGB,UGP2B,PYGMA,UGT1A6B |
Protein Function
GBA3 has several biochemical functions, for example, beta-galactosidase activity,beta-glucosidase activity,glycosylceramidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GBA3 itself. We selected most functions GBA3 had, and list some proteins which have the same functions with GBA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-galactosidase activity | GLB1L3,GLB1L,GLB1L2,GLB1 |
| beta-glucosidase activity | GBA2 |
Interacting Protein
GBA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GBA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GBA3.
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References
- Wang, SY; Fu, LL; et al. In silico analysis and experimental validation of active compounds from fructus Schisandrae chinensis in protection from hepatic injury. CELL PROLIFERATION 48:86-94(2015).
- Kallemeijn, WW; Witte, MD; et al. A Sensitive Gel-based Method Combining Distinct Cyclophellitol-based Probes for the Identification of Acid/Base Residues in Human Retaining beta-Glucosidases. JOURNAL OF BIOLOGICAL CHEMISTRY 289:35351-35362(2014).
