GATA5

  • Official Full Name

    GATA binding protein 5

  • Overview

    The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.

  • Synonyms

    GATA5;GATA binding protein 5;transcription factor GATA-5;bB379O24.1;GATA-binding factor 5;GATA5_HUMAN;GATA binding factor-5;GATA-binding protein 5

Recombinant Proteins

  • Mouse
  • Chicken
  • Zebrafish
  • Rat
  • Human
  • Mammalian Cell
  • E.coli
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • His
  • His&Fc&Avi
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
GATA5-6226M Recombinant Mouse GATA5 Protein Mammalian Cell Mouse His
GATA5-6972C Recombinant Chicken GATA5 Mammalian Cell Chicken His
GATA5-8834Z Recombinant Zebrafish GATA5 Mammalian Cell Zebrafish His
Gata5-1567M Recombinant Mouse Gata5 Protein, His-tagged E.coli Mouse His Met1-Leu401
Gata5-1568R Recombinant Rat Gata5 Protein, His-tagged E.coli Rat His Met1-Ala397
GATA5-3484M Recombinant Mouse GATA5 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
GATA5-3484M-B Recombinant Mouse GATA5 Protein Pre-coupled Magnetic Beads HEK293 Mouse
GATA5-4751H Recombinant Human GATA5 Protein, GST-tagged Wheat Germ Human GST
GATA5-5470HF Recombinant Full Length Human GATA5 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 397 amino acids

    Involved Pathway

    GATA5 involved in several pathways and played different roles in them. We selected most pathways GATA5 participated on our site, such as Factors involved in megakaryocyte development and platelet production,Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hemostasis CENPE,CEACAM6,DOCK11,SCG3,CFD,CFHL4,GLG1B,KIF5B,HBG1,SERPINA1L
    Factors involved in megakaryocyte development and platelet production KDM1A,EHD1,KIFAP3,HBBE1.1,KIF3A,RACGAP1,GATA2A,AKAP1B,BA2,KIF5B

    Protein Function

    GATA5 has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA5 itself. We selected most functions GATA5 had, and list some proteins which have the same functions with GATA5. You can find most of the proteins on our site.

    Function Related Protein
    zinc ion binding BRAP,KDM7AB,CSRP1B,ATXN7L3,PRKCBA,HDAC6,HERC2,MMP28,RNF38,RAG1
    transcription factor activity, sequence-specific DNA binding ZNF484,ZNF74,ZNF217,FOXP1B,CREB5,E2F8,RARAB,FOSL2,ZFP518A,ZNF227
    metal ion binding NUDT1,GTF2H3,ACLYA,RNF169,ZDHHC16,ZDHHC1,CPEB1B,ZFP91,ADH8A,ARAF
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding HIF1A,SPI1,LEF1,PDX1,RFX3,USF2,POU4F1,CEBPB,HNF4A,HNF1B
    sequence-specific DNA binding FOXG1A,FOXC1A,GRHL2B,MYOG,MNX2B,TLX3,FOXI3B,NR2F6A,GLI2,NR4A2B
    DNA binding VOX,ORC1L,RARGA,ETV5A,TRIM33,HIST1H2AB,PCBP2,JUNBA,MEF2CB,SP8B
    RNA polymerase II transcription factor binding HCLS1,SMAD4,GATA2B,Ar,PITX2,GATA3,GATA1,TOX2,TEAD3,GSC
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ATF5,BARHL2,NHLH1,FOXO3,MYOD1,GRHL2,ATF2,ZGLP1,TBX5,HOXD8
    chromatin binding SIRT2,STAG1,CALCOCO1,ASH1L,HDAC3,APTX,CITED2,NCOA5,SMARCD3,MPO

    Interacting Protein

    GATA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA5.

    Resources

    References

    • Zhang, XL; Dai, N; et al. GATA5 loss-of-function mutation in familial dilated cardiomyopathy. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 35:763-770(2015).
    • Wang, J; Mao, JH; et al. A Novel NKX2.6 Mutation Associated with Congenital Ventricular Septal Defect. PEDIATRIC CARDIOLOGY 36:646-656(2015).

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