GATA4
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Official Full Name
GATA binding protein 4 -
Overview
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects. [provided by RefSeq, Jul 2008] -
Synonyms
GATA4;GATA binding protein 4;ASD2;VSD1;TACHD;transcription factor GATA-4;GATA-binding factor 4
Recombinant Proteins
- Rat
- Human
- Chicken
- Zebrafish
- Mouse
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- HEK293T
- Mammalian cells
- His
- Non
- His&Fc&Avi
- His&Myc
- Myc&DDK
- Flag
Involved Pathway
GATA4 involved in several pathways and played different roles in them. We selected most pathways GATA4 participated on our site, such as cGMP-PKG signaling pathway,Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone signaling pathway | PIK3R1,ITGAV,THRA,TRP53,MED30,WNT4,CASP9,SRC,PLCG2,EP300 |
| cGMP-PKG signaling pathway | RHOA,PPP3CA,RGS2,NFATC1,VDAC3,PPP3CC,ATP1A2,AGTR1B,LOC100328615,INS |
Protein Function
GATA4 has several biochemical functions, for example, DNA binding,NFAT protein binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA4 itself. We selected most functions GATA4 had, and list some proteins which have the same functions with GATA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, RNA polymerase II transcription factor binding | MAMSTR,ATF2,YAP1,HIF1A,GTF2E1,LHX2,NACC2,ATF4,MYOCD,THRAA |
| protein kinase binding | AXIN1,PPP1CB,FAM83B,PPME1,RHOD,IBTK,CD24,EPHA1,SHC1,CCNL1B |
| zinc ion binding | PAM,RBM10,RBM14A,SMAD3,SEC23B,MMP25,LIMS3,ALAD,GTF2B,ADH6 |
| transcription coactivator activity | JUNB,TDRD3,SERTAD2,Ankar,ATF2,TADA1,CITED1,TCF3,AIP,NFATC4 |
| RNA polymerase II regulatory region sequence-specific DNA binding | H2AFY,ZNF480,RUNX3,SP5,NKX2-1,DMRT1,NEUROD2,RARG,AASS,HMX1 |
| chromatin binding | TOP2B,SREBF1,STAG2,MEOX1,PDX1,TFAP2A,ORC1L,CDCA5,NEUROD1,POLG |
| co-SMAD binding | SMAD3,SMAD2,TGIF1,SMAD6,CITED1,TRIM33,SMAD1,USP9X,FOXH1 |
| DNA binding | TCEB3C,NFIXB,ABT1,ARHGAP35,FOXQ1B,ZNF490,TCEA2,HIST3H3,CERS5,LASS4 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | POU4F1,ATF2,MITF,NFIX,NKX2,SFPI1,RFX1,SOX10,JUN,MYOG |
Interacting Protein
GATA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA4.
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References
- Yamak, A; Georges, RO; et al. Novel Exons in the Tbx5 Gene Locus Generate Protein Isoforms with Distinct Expression Domains and Function. JOURNAL OF BIOLOGICAL CHEMISTRY 290:6844-6856(2015).
- Zheng, Y; Thomas, A; et al. Quantitative detection of human spermatogonia for optimization of spermatogonial stem cell culture. HUMAN REPRODUCTION 29:2497-2511(2014).
