GAS2
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Official Full Name
growth arrest-specific 2 -
Overview
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. -
Synonyms
GAS2;growth arrest-specific 2;growth arrest-specific protein 2;GAS-2;MGC32610
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- S.cerevisiae
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- P. pastoris
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
- Myc&DDK
Involved Pathway
GAS2 involved in several pathways and played different roles in them. We selected most pathways GAS2 participated on our site, such as Apoptosis,Apoptotic cleavage of cellular proteins,Apoptotic execution phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptotic execution phase | HIST1H1B,DBNL,DBNLA,SATB1,STK24A,CLSPN,OCLN,CASP6L1,PLEC,STK26 |
| Apoptotic cleavage of cellular proteins | DBNLA,LMNB1,SPNA2,PTBP3,CLSPN,DSG1,DSG3,VIML,DSG2,DSP |
| Programmed Cell Death | DIABLO,PANK1A,DSP,PLECA,RNF8,SATB1,PKP1,GZMF,ADD1,HMGB2 |
| Caspase-mediated cleavage of cytoskeletal proteins | DBNLB,ADD1,CASP6L2,PLEC,VIML,DBNLA,PLECA,DBNL,SPNA2,CASP6L1 |
| Apoptosis | IRF2A,CAPN2L,DSG2,PRKACG,IRAK3,BMX,NTRK1,PRKAR1AB,CAPN2,BIRC8 |
| Caspase cascade in apoptosis | PARP1,CFL2,DFFA,LMNB1,ACTA1,CRADD,TFAP2A,TOP1,DIABLO,CASP4 |
Protein Function
GAS2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by GAS2 itself. We selected most functions GAS2 had, and list some proteins which have the same functions with GAS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
GAS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAS2.
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