GAPVD1
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Official Full Name
GTPase activating protein and VPS9 domains 1 -
Overview
GAPex 5 plays a role in several processes such as endocytosis, insulin receptor internalisation and LC2A4/GLUT4 trafficking. It acts as both a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF). GAPex 5 is a GEF for the small G protein Rab31, promoting the exchange of GDP bound to Rab31 for GTP and thus regulating LC2A4/GLUT4 trafficking. In the absence of insulin, GAPex 5 maintains Rab31 in an active (GTP-bound) state, thereby promoting a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, keeping LC2A4/GLUT4 inside the cells. Following insulin stimulation, GAPex 5 is translocated to the plasma membrane, enabling the release of LC2A4/GLUT4 from the intracellular storage vesicles. GAPex 5 is also involved in EGFR trafficking and degradation, and also has GEF activity for Rab5 and GAP activity for Ras. -
Synonyms
GAPVD1;GTPase activating protein and VPS9 domains 1;RAP6;GAPEX5;GAPex-5;GTPase-activating protein and VPS9 domain-containing protein 1;rab5-activating protein 6
Recombinant Proteins
- Chicken
- Zebrafish
- Mouse
- Human
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GAPVD1-5440C | Recombinant Chicken GAPVD1 | Mammalian Cell | Chicken | His |
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| GAPVD1-556Z | Recombinant Zebrafish GAPVD1 | Mammalian Cell | Zebrafish | His |
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| GAPVD1-6208M | Recombinant Mouse GAPVD1 Protein | Mammalian Cell | Mouse | His |
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| GAPVD1-686HCL | Recombinant Human GAPVD1 cell lysate | Human | Non |
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| GAPVD1-3467M | Recombinant Mouse GAPVD1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GAPVD1-3467M-B | Recombinant Mouse GAPVD1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GAPVD1-4728H | Recombinant Human GAPVD1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GAPVD1-5440HF | Recombinant Full Length Human GAPVD1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 629 amino acids |
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Involved Pathway
GAPVD1 involved in several pathways and played different roles in them. We selected most pathways GAPVD1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GAPVD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
GAPVD1 has several biochemical functions, for example, GTPase activating protein binding,GTPase activator activity,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GAPVD1 itself. We selected most functions GAPVD1 had, and list some proteins which have the same functions with GAPVD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | CDC42EP4A,LLGL1,CDC42EP3,TBC1D7,DEPDC1,SMAP2,ARFGAP2,ALS2CL,RGS16,RASA3 |
| guanyl-nucleotide exchange factor activity | SPATA13,RINL,DOCK6,RAPGEF5B,ARHGEF37,FAM116B,RAPGEF1B,DOCK7,ARHGEF11,BCAR3 |
| GTPase activating protein binding | PTBP3,TSC1,GNAI1,RGS14,FMNL1,TUBB,GNAO1,CDH1,PIN1,MEX3B |
Interacting Protein
GAPVD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAPVD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAPVD1.
YWHAB;YWHAZ;Csnk1e;HSPB1;VAV2;pi3p;bosutinib;dasatinib
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