GAPDHS
-
Official Full Name
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -
Overview
This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. -
Synonyms
GAPDHS;glyceraldehyde-3-phosphate dehydrogenase, spermatogenic;GAPDS;glyceraldehyde-3-phosphate dehydrogenase, testis-specific;GAPD2;GAPDH 2;spermatogenic glyceraldehyde-3-phosphate dehydrogenase;spermatogenic cell-specific glyceraldehyde 3-phospha
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
GAPDHS involved in several pathways and played different roles in them. We selected most pathways GAPDHS participated on our site, such as Glycolysis / Gluconeogenesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAPDHS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycolysis / Gluconeogenesis | ALDH3A2A,PGM1,PKMB,FBP1A,pykF,ENO1A,ADH1B,ADH6,PCK2,FBP2 |
| Metabolic pathways | ACAT1,PIGW,ADSL,POLR3C,GGT7,FH1,ENOPH1,MBOAT2,SPRA,GMDS |
Protein Function
GAPDHS has several biochemical functions, for example, NAD binding,NADP binding,glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GAPDHS itself. We selected most functions GAPDHS had, and list some proteins which have the same functions with GAPDHS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | GAPDH |
| NAD binding | IDH3G,PHGDH,NDUFS2,HIBADHA,GPD1C,HIBADH,GPD1,HSD11B2,CYB5R3,HSD17B10 |
| NADP binding | SPR,NOS2,MIOX,GAPDH,CRYM,MTRR,H6PD,NNT,MTHFR,HMGCRA |
| protein binding | SPZ1,DYNC1I1,PROM1,FAM154A,DDB2,GNPDA1,PAEP,NFE2L1,GLMN,TPD52L2 |
Interacting Protein
GAPDHS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAPDHS here. Most of them are supplied by our site. Hope this information will be useful for your research of GAPDHS.
NTHL1;SH3BP4;MDM2
Resources
Related Services
Related Products
References
- Cao, TT; Tsai, MA; et al. Vaccine efficacy of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from Edwardsiella ictaluri against E-tarda in tilapia. JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY 60:241-250(2014).
- Dorosh, A; et al. Monoclonal Antibody 6E4 Against Human GAPDHS Protein. HYBRIDOMA 30:321-321(2011).
