GALR2
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Official Full Name
galanin receptor 2 -
Overview
Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. -
Synonyms
GALR2;galanin receptor 2;galanin receptor type 2;GALNR2;GAL2-R;GALR-2;MGC125983;MGC125984
Recombinant Proteins
- Rat
- Chicken
- Mouse
- Human
- Mus musculus
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
GALR2 involved in several pathways and played different roles in them. We selected most pathways GALR2 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | ADRB2A,CHRNA4,NPFFR2,LEPB,S1PR5A,CALCRL,GRID2,GHSRA,F2RL1,TAAR7F |
Protein Function
GALR2 has several biochemical functions, for example, galanin receptor activity,peptide hormone binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GALR2 itself. We selected most functions GALR2 had, and list some proteins which have the same functions with GALR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| galanin receptor activity | GALR3,GALR1,GAL |
| protein binding | ZKSCAN17,F2R,LTC4S,RBMX,SPRY2,RAB4B,SEMA4A,MFN2,SLC25A10,CCDC146 |
| peptide hormone binding | INHBA,NPR1,GHR,PTH1R,PRLR,RXFP2,MC4R,AGTR1B,GIPR,ANXA5 |
Interacting Protein
GALR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GALR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GALR2.
GAL;NPY1R
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References
- Misawa, K; Misawa, Y; et al. Aberrant Methylation Inactivates Somatostatin and Somatostatin Receptor Type 1 in Head and Neck Squamous Cell Carcinoma. PLOS ONE 10:-(2015).
- Metcalf, CS; Klein, BD; et al. Analgesic Properties of a Peripherally Acting and GalR2 Receptor-Preferring Galanin Analog in Inflammatory, Neuropathic, and Acute Pain Models. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 352:185-193(2015).
