GALNT9
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Official Full Name
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9) -
Overview
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. This gene is expressed specifically in the brain, with highest expression in the cerebellum. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
GALNT9;UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9);polypeptide N-acetylgalactosaminyltransferase 9;GALNAC T9;Polypeptide GalNAc transferase 9;Polypeptide N acetylgalactosaminyltransferase 9;pp GaNTase 9;Protein UDP acetylgalactosaminyltransferase 9;UDP GalNAc polypeptide N acetylgalactosaminyltransferase 9;pp-GaNTase 9;GalNAc transferase 9;protein-UDP acetylgalactosaminyltransferase 9;UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 9;UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase 9;GALNAC-T9
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GALNT9-6033HCL | Recombinant Human GALNT9 293 Cell Lysate | HEK293 | Human | Non |
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| GALNT9-1254H | Recombinant Human GALNT9 Protein, His-tagged | E.coli | Human | His |
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| GALNT9-4708H | Recombinant Human GALNT9 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GALNT9-5303HF | Recombinant Full Length Human GALNT9 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 237 amino acids |
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Involved Pathway
GALNT9 involved in several pathways and played different roles in them. We selected most pathways GALNT9 participated on our site, such as Mucin type O-Glycan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALNT9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mucin type O-Glycan biosynthesis | B4GALT5,GALNT1,GCNT4,POC1BL,GALNT5,GALNT7,GALNTL2,C1GALT1,GALNT10,GCNT4A |
| Metabolic pathways | NME4,GBGT1L4,GALCB,EXT1C,DAD1,CYP4F3,IVD,HGSNAT,aLA,CTPS1A |
Protein Function
GALNT9 has several biochemical functions, for example, carbohydrate binding,metal ion binding,polypeptide N-acetylgalactosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GALNT9 itself. We selected most functions GALNT9 had, and list some proteins which have the same functions with GALNT9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | CLEC10A,HBL3,GALNT12,GALNT14,CD55,PKD1L3,GFPT2,OLR1,CHODL,CLEC4E |
| polypeptide N-acetylgalactosaminyltransferase activity | GALNT3,GALNT11,GALNTL2,GALNT14,GALNT4,GALNT2,C1GALT1C1,GALNT5,GALNT13,GALNT1 |
| metal ion binding | ARID2,PXDN,ATX1,ZNF114,PDE6A,PPM1LA,TAX1BP1B,WTIP,ATP1A3B,TRIM35-28 |
Interacting Protein
GALNT9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GALNT9 here. Most of them are supplied by our site. Hope this information will be useful for your research of GALNT9.
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References
- Tuupanen, S; Hanninen, UA; et al. Identification of 33 candidate oncogenes by screening for base-specific mutations. BRITISH JOURNAL OF CANCER 111:1657-1662(2014).
- Nakayama, Y; Nakamura, N; et al. Identification and expression analysis of zebrafish polypeptide alpha-N-acetylgalactosaminyltransferase Y-subfamily genes during embryonic development. GENE EXPRESSION PATTERNS 16:1-7(2014).
