GALNT6

  • Official Full Name

    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)

  • Overview

    This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin.

  • Synonyms

    GALNT6;UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6);polypeptide N-acetylgalactosaminyltransferase 6;GALNAC T6;GalNAc transferase 6;GalNAcT6;GALNT 6;Polypeptide GalNAc transferase 6;Polypeptide N acetylgalactosaminyltransferase 6;pp GaNTase 6;Protein UDP acetylgalactosaminyltransferase 6;UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 6;UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 6 (GalNAc T6);UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 6;pp-GaNTase 6;protein-UDP acetylgalactosaminyltransferase 6;UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6;UDP-N-acetyl-alpha-D-galactosamine:;GALNAC-T6

Recombinant Proteins

  • Zebrafish
  • Human
  • Chicken
  • Mouse
  • Mammalian Cell
  • HEK293
  • HEK293T
  • Wheat Germ
  • In Vitro Cell Free System
  • His
  • Myc&DDK
  • Non
  • His&Fc&Avi
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
GALNT6-12406Z Recombinant Zebrafish GALNT6 Mammalian Cell Zebrafish His
GALNT6-22H Recombinant Human GALNT6 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
GALNT6-3219C Recombinant Chicken GALNT6 Mammalian Cell Chicken His
GALNT6-6189M Recombinant Mouse GALNT6 Protein Mammalian Cell Mouse His
GALNT6-6035HCL Recombinant Human GALNT6 293 Cell Lysate HEK293 Human Non
Galnt6-3144M Recombinant Mouse Galnt6 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
GALNT6-3453M Recombinant Mouse GALNT6 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
GALNT6-3453M-B Recombinant Mouse GALNT6 Protein Pre-coupled Magnetic Beads HEK293 Mouse
GALNT6-4704H Recombinant Human GALNT6 Protein, GST-tagged Wheat Germ Human GST
GALNT6-5268HF Recombinant Full Length Human GALNT6 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 622 amino acids
GALNT6-6318H Recombinant Human GALNT6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK

    Involved Pathway

    GALNT6 involved in several pathways and played different roles in them. We selected most pathways GALNT6 participated on our site, such as Metabolic pathways,Metabolism of proteins,Mucin type O-Glycan biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALNT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism of proteins FBXW9,ADAMTSL5,EXOC8,LDHD,ALG14,PFDN1,PREB,ST6GAL2B,NSFA,TIMM17A
    O-linked glycosylation of mucins MUC15,MUC4,MUC12,MUC20,B3GNT2A,A4GNT,MUC21,MUC1,GCNT3,GALNTL5
    O-linked glycosylation A4GNT,ADAMTS20,ADAMTS18,ADAMTS15,MUC5AC,MUC12,SPON1,ADAMTSL5,ADAMTS5,B3GNT6
    mucin core 1 and core 2 O-glycosylation GALNT5,GALNTL2,GALNT13,GCNT3
    Post-translational protein modification ADAMTSL4,CBX4,PPP6C,DNAJC24,SEC23IP,TRAPPC6A,CNIH3,ATPBD4,BET1,KCNA6
    Mucin type O-Glycan biosynthesis GCNT3,ST3GAL2,B4GALT5,GALNT5,POC1BL,POC1B-GALNT4,GALNT7,GALNT2,GALNT11,GALNT4
    Metabolic pathways GGT1,BCO1,PLA2G3,ALOX15,FUT7,PCYT1AA,PFKP,GALNTL1,TKTL2,POLE2

    Protein Function

    GALNT6 has several biochemical functions, for example, carbohydrate binding,metal ion binding,polypeptide N-acetylgalactosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GALNT6 itself. We selected most functions GALNT6 had, and list some proteins which have the same functions with GALNT6. You can find most of the proteins on our site.

    Function Related Protein
    polypeptide N-acetylgalactosaminyltransferase activity GALNT1,GALNTL1,GALNT12,GALNT9,GALNTL4,GALNT13,C1GALT1C1,GALNT11,GALNT2,GALNT14
    metal ion binding IDS,ZNF625,ATP2B2,CYP2A12,PKMYT1,ITGA6,PRDM15,ZFP426,POLR2A,TRIM3B
    carbohydrate binding GALNTL4,PRG2,FCN1,NOMO1,ATRN,LGALSLA,KLRA8,LGALS13,CLEC1B,EVA1C

    Interacting Protein

    GALNT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GALNT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GALNT6.

    ALDOA;TMEM9;SLC5A6;AK6

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