GALNT4

  • Official Full Name

    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)

  • Overview

    This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon. Fusion transcripts, which combine part of this gene with the 5 exons of the neighboring POC1B (POC1 centriolar protein homolog B) gene, also exist.

  • Synonyms

    GALNT4;UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4);polypeptide N-acetylgalactosaminyltransferase 4;GalNAc T4;EC 2.4.1.41;GalNAc transferase 4;GalNAc-T4;GalNAcT4;GALT4_HUMAN;N-acetylgalactosaminyltransferase 4 (GalNAc-T4);Polypeptide GalNAc transferase 4;pp GaNTase 4;pp-GaNTase 4;Protein UDP acetylgalactosaminyltransferase 4;Protein-UDP acetylgalactosaminyltransferase 4;UDP GalNAc:polypeptide N-acetylgalactosaminyltransferase 4;UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4;UDP-N-acetyl-alpha-D-galactosamine:polypeptide

Recombinant Proteins

  • Rhesus macaque
  • Mouse
  • Human
  • Mus musculus
  • Mammalian Cell
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • E.coli expression system
  • His
  • Non
  • His&Fc&Avi
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
GALNT4-1808R Recombinant Rhesus monkey GALNT4 Protein, His-tagged Mammalian Cell Rhesus macaque His
GALNT4-6187M Recombinant Mouse GALNT4 Protein Mammalian Cell Mouse His
GALNT4-6036HCL Recombinant Human GALNT4 293 Cell Lysate HEK293 Human Non
GALNT4-1629R Recombinant Rhesus Macaque GALNT4 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
GALNT4-1629R-B Recombinant Rhesus Macaque GALNT4 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
GALNT4-3452M Recombinant Mouse GALNT4 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
GALNT4-3452M-B Recombinant Mouse GALNT4 Protein Pre-coupled Magnetic Beads HEK293 Mouse
GALNT4-4703H Recombinant Human GALNT4 Protein, GST-tagged Wheat Germ Human GST
GALNT4-5267HF Recombinant Full Length Human GALNT4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 40-578 amino acids
RFL24290MF Recombinant Full Length Mouse Polypeptide N-Acetylgalactosaminyltransferase 4(Galnt4) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length (1-578)

    Involved Pathway

    GALNT4 involved in several pathways and played different roles in them. We selected most pathways GALNT4 participated on our site, such as Mucin type O-Glycan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALNT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolic pathways AGPAT9,GAMT,IDH1,PNAT10,FUT8A,CES1C,ITPK1,POLR2K,CECR1,ALDOB
    Mucin type O-Glycan biosynthesis GALNTL1,B4GALT5,C1GALT1,GALNT9,WBSCR17,GALNT13,GCNT3,C1GALT1C1,GALNT3,GALNT2

    Protein Function

    GALNT4 has several biochemical functions, for example, carbohydrate binding,metal ion binding,polypeptide N-acetylgalactosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GALNT4 itself. We selected most functions GALNT4 had, and list some proteins which have the same functions with GALNT4. You can find most of the proteins on our site.

    Function Related Protein
    polypeptide N-acetylgalactosaminyltransferase activity GALNT6,GALNT9,GALNT11,GALNT5,GALNTL4,GALNTL6,GALNT7,WBSCR17,GALNT1,GALNTL1
    metal ion binding ZNF829,RPE65,ZMIZ2,FGD6,DZIP1,SCNM1-PS,TGM5,NUDT13,CYP2C50,ATP8B5
    carbohydrate binding GALNT10,PKD1L3,PRG3,LPHN1,LGALS4,MAG,LMAN1L,CD33,CLEC12A,CLEC2H

    Interacting Protein

    GALNT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GALNT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GALNT4.

    Resources

    References

    • Erbilgin, A; Civelek, M; et al. Identification of CAD candidate genes in GWAS loci and their expression in vascular cells. JOURNAL OF LIPID RESEARCH 54:1894-1905(2013).
    • Liu, YD; Liu, WS; et al. GALNT4 Predicts Clinical Outcome in Patients with Clear Cell Renal Cell Carcinoma. JOURNAL OF UROLOGY 192:1534-1541(2014).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All GALNT4 Products

    Required fields are marked with *

    My Review for All GALNT4 Products

    Required fields are marked with *