GALNT12
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Official Full Name
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12) -
Overview
This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer. -
Synonyms
GALNT12;UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12);polypeptide N-acetylgalactosaminyltransferase 12;FLJ21212;CRCS1;GalNAc T12;GalNAc-T12;GalNAcT12;GALNT 12;GLT12_HUMAN;Polypeptide GalNAc transferase 12;Polypeptide N acetylgalactosaminyltransferase 12;pp GaNTase 12;pp-GaNTase 12;Protein UDP acetylgalactosaminyltransferase 12;Protein-UDP acetylgalactosaminyltransferase 12;UDP GalNAc polypeptide N acetylgalactosaminyltransferase 12;UDP GalNAc polypeptide N acetylgalactosaminyltransferase;UDP N acetyl alpha D galactosamine polypeptide N acetylgalactosaminyltransferase 12;UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12;OTTHUMP00000021781;colorectal cancer, susceptibility to 1
Recombinant Proteins
- Human
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GALNT12-13133H | Recombinant Human GALNT12, GST-tagged | E.coli | Human | GST | C-term-272a.a. | |
| GALNT12-1806R | Recombinant Rhesus monkey GALNT12 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| GALNT12-681HCL | Recombinant Human GALNT12 cell lysate | Human | Non |
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| GALNT12-1627R | Recombinant Rhesus Macaque GALNT12 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| GALNT12-1627R-B | Recombinant Rhesus Macaque GALNT12 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| GALNT12-4692H | Recombinant Human GALNT12 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GALNT12-5143HF | Recombinant Full Length Human GALNT12 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 272 amino acids |
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Involved Pathway
GALNT12 involved in several pathways and played different roles in them. We selected most pathways GALNT12 participated on our site, such as Mucin type O-Glycan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALNT12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | GATB,PLCD3,PON2,GLSA,AADAT,PRPS1A,ACAT2,DNMT1,CYP2C50,PLCB4 |
| Mucin type O-Glycan biosynthesis | GALNTL1,C1GALT1C1,C1GALT1B,GALNT1,GCNT1,GALNTL5,WBSCR17,ST6GALNAC1,POC1B-GALNT4,GALNTL2 |
Protein Function
GALNT12 has several biochemical functions, for example, carbohydrate binding,metal ion binding,polypeptide N-acetylgalactosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GALNT12 itself. We selected most functions GALNT12 had, and list some proteins which have the same functions with GALNT12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| polypeptide N-acetylgalactosaminyltransferase activity | GALNT10,GALNT2,GALNT6,GALNT7,WBSCR17,GALNTL4,GALNT1,GALNT5,GALNTL6,GALNTL2 |
| metal ion binding | MPPED2,PDE7B,POGZA,NFS1,MGAT4B,YBEY,HBBE2,CLCNKA,ZMYM2,ROR2 |
| carbohydrate binding | LGALS3L,GALNT2,GALNT4,CLEC2G,CD209C,FCN1,CLEC4F,ZG16B,GALNT9,CD22 |
Interacting Protein
GALNT12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GALNT12 here. Most of them are supplied by our site. Hope this information will be useful for your research of GALNT12.
BUB1;RB1;CDH1;SRC;BMPR1A;PIK3CA;MSH2;PMS2;CDKN2A;FBXW7;MLH3
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References
- Wang, X; Ju, LG; et al. Histone H3K4 methyltransferase Mll1 regulates protein glycosylation and tunicamycin-induced apoptosis through transcriptional regulation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1843:2592-2602(2014).
- Hussain, MRM; Nasir, J; et al. Clinically Significant Missense Variants in Human GALNT3, GALNT8, GALNT12, and GALNT13 Genes: Intriguing In Silico Findings. JOURNAL OF CELLULAR BIOCHEMISTRY 115:313-327(2014).
