GALNT11
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Official Full Name
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11) -
Overview
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward Muc1, Muc4.1, and EA2 than GALNT1. Does not appear to be involved in glycosylation of erythropoietin. -
Synonyms
GALNT11;UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11);polypeptide N-acetylgalactosaminyltransferase 11;FLJ21634;GALNAC-T11;pp-GaNTase 11;polypeptide GalNAc transferase 11;protein-UDP acetylgalactos
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GALNT11-4470Z | Recombinant Zebrafish GALNT11 | Mammalian Cell | Zebrafish | His |
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| GALNT11-6181M | Recombinant Mouse GALNT11 Protein | Mammalian Cell | Mouse | His |
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| GALNT11-001H | Active Recombinant Human GALNT11 Protein, His-tagged | CHO | Human | His | 30-608 a.a. |
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| GALNT11-3449M | Recombinant Mouse GALNT11 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GALNT11-3449M-B | Recombinant Mouse GALNT11 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
GALNT11 involved in several pathways and played different roles in them. We selected most pathways GALNT11 participated on our site, such as Mucin type O-Glycan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALNT11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | AGLA,ATP6V1G3,PSAT1,GPI,GALNTL4,NAMPTB,GLYCTK,HKDC1,TK1,CD38 |
| Mucin type O-Glycan biosynthesis | POC1BL,GALNT3,GALNT18A,GCNT3,B4GALT5,GCNT4A,GALNT6,GALNTL1,GALNT7,C1GALT1 |
Protein Function
GALNT11 has several biochemical functions, for example, Notch binding,carbohydrate binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GALNT11 itself. We selected most functions GALNT11 had, and list some proteins which have the same functions with GALNT11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Notch binding | C8orf4,ADAM17,NOTCH4,JAG1B,JAG2,HIF1AN,NCOR2,DTX1,JAG1,DLL3 |
| carbohydrate binding | GALNT2,REG1A,Siglece,CLEC12A,FCNA,ASGR2,PRG2,POC1BL,SIGLEC12,SIGLEC5 |
| transferase activity, transferring glycosyl groups | PNP4A,PIGB,UGT2B5,UGT5D1,UGT1B3,ST3GAL2L,UGT1A5,ST3GAL3A,4931440L10Rik,FUT9B |
| polypeptide N-acetylgalactosaminyltransferase activity | GALNTL2,GALNT7,GALNT14,GALNT10,GALNT2,GALNT6,GALNTL4,GALNT12,C1GALT1C1,GALNT3 |
| metal ion binding | ACACB,TIMP2,TRIM3B,TSSK5,CYP21A1,NR5A1B,CAR3,DPEP2,CYP2C70,WT1B |
| transferase activity | C1GALT1B,UGT5C3,MARCKSA,EHMT1B,NEK5,KITA,CHST2A,TNIKA,METTL8,MAT2AL |
Interacting Protein
GALNT11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GALNT11 here. Most of them are supplied by our site. Hope this information will be useful for your research of GALNT11.
Ywhaz;Hsd3b4
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References
- Yuasa, I; Umetsu, K; et al. Investigation of Japanese-specific alleles: Most are of Jomon lineage. LEGAL MEDICINE 17:52-55(2015).
- Libisch, MG; Casas, M; et al. GALNT11 as a new molecular marker in chronic lymphocytic leukemia. GENE 533:270-279(2014).
