GABRG1
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Official Full Name
gamma-aminobutyric acid (GABA) A receptor, gamma 1 -
Overview
The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4. -
Synonyms
GABRG1;gamma-aminobutyric acid (GABA) A receptor, gamma 1;gamma-aminobutyric acid receptor subunit gamma-1;GABA(A) receptor;gamma;gamma-1 polypeptide;GABA(A) receptor, gamma;GABA(A) receptor subunit gamma-1;MGC33838;DKFZp686H2042
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GABRG1-13102H | Recombinant Human GABRG1, GST-tagged | E.coli | Human | GST | 38-271a.a. | |
| GABRG1-2452R | Recombinant Rat GABRG1 Protein | Mammalian Cell | Rat | His |
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| GABRG1-6154M | Recombinant Mouse GABRG1 Protein | Mammalian Cell | Mouse | His |
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| GABRG1-6058HCL | Recombinant Human GABRG1 293 Cell Lysate | HEK293 | Human | Non |
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| GABRG1-2108R | Recombinant Rat GABRG1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| GABRG1-2108R-B | Recombinant Rat GABRG1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GABRG1-3433M | Recombinant Mouse GABRG1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GABRG1-3433M-B | Recombinant Mouse GABRG1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GABRG1-4650H | Recombinant Human GABRG1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GABRG1-5201HF | Recombinant Full Length Human GABRG1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 465 amino acids |
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Involved Pathway
GABRG1 involved in several pathways and played different roles in them. We selected most pathways GABRG1 participated on our site, such as Neuroactive ligand-receptor interaction,Retrograde endocannabinoid signaling,GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABRG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | LPAR3,GABRA3,GRM4,S1PR4,GRIN2A,IL12,PRLR,LHB,P2RX7,TACR3A |
| Nicotine addiction | GABRA2,GRIN2C,GABRG3,SLC17A8,GABRR1,GRIA4,GABRA3,GRIN3B,GRIN2B,GRIA1 |
| GABAergic synapse | GABRE,GNG4,GABRG2,SLC12A5,GABRD,GABRA1,GABRA5,GABRB3,PRKACG,GNAI3 |
| Retrograde endocannabinoid signaling | GABRP,GABRA3,PRKCG,GNB1,GABRR3,GABRA6,GNGT1,ITPR1,GABRB1,ITPR3 |
Protein Function
GABRG1 has several biochemical functions, for example, GABA receptor binding,contributes_to GABA-A receptor activity,contributes_to benzodiazepine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GABRG1 itself. We selected most functions GABRG1 had, and list some proteins which have the same functions with GABRG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to GABA-A receptor activity | GABRR2A,GABRA6,GABRA2,GABRR3A,GABRA4,GABRA3,GABRZ,GABRQ,GABRA6A,GABRG3 |
| contributes_to benzodiazepine receptor activity | GABRG3,GABRA1,GABRE,GABRA5,GABRA6A |
| chloride channel activity | GABRR1,SLC26A1,TTYH3,CLCNKB,TTYH2,APOL1,SLC26A7,FXYD3,GABRB2,GABRE |
| GABA receptor binding | PLCL1,GABARAPL2,PLCL2,AKAP5,TRAK1,MAF1,GABARAPA,JAKMIP1,PPP2CA,GABARAPL1 |
| inhibitory extracellular ligand-gated ion channel activity | GABRG3,GABRE,GABRA3,GABRA2,GABRA5,GABRA1,GABRA6,GABRA6A,GABRA4,GABRB2 |
Interacting Protein
GABRG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABRG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GABRG1.
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References
- Wang, XP; Cheng, ZY; et al. GABA(B) receptors are expressed in human aortic smooth muscle cells and regulate the intracellular Ca2+ concentration. HEART AND VESSELS 30:249-257(2015).
- Blankenburg, S; Balfanz, S; et al. Cockroach GABA(B) receptor subtypes: Molecular characterization, pharmacological properties and tissue distribution. NEUROPHARMACOLOGY 88:134-144(2015).
