GABRE
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Official Full Name
gamma-aminobutyric acid (GABA) A receptor, epsilon -
Overview
The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. -
Synonyms
GABRE;gamma-aminobutyric acid (GABA) A receptor, epsilon;gamma-aminobutyric acid receptor subunit epsilon;GABA(A) receptor;epsilon;GABA(A) receptor, epsilon;GABA(A) receptor subunit epsilon
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GABRE-13101H | Recombinant Human GABRE, His-tagged | E.coli | Human | His | 28-279a.a. | |
| GABRE-6798C | Recombinant Chicken GABRE | Mammalian Cell | Chicken | His |
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| GABRE-6059HCL | Recombinant Human GABRE 293 Cell Lysate | HEK293 | Human | Non |
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| GABRE-1553H | Recombinant Human GABRE Protein, His-tagged | E.coli | Human | His | Pro23-Lys253 |
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| GABRE-4648H | Recombinant Human GABRE Protein, GST-tagged | Wheat Germ | Human | GST |
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| GABRE-5200HF | Recombinant Full Length Human GABRE Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 365 amino acids |
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Involved Pathway
GABRE involved in several pathways and played different roles in them. We selected most pathways GABRE participated on our site, such as Neuroactive ligand-receptor interaction,Retrograde endocannabinoid signaling,GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABRE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | PTGER1,P2RX8,F2RL2,GRM2A,GHSR,PTGER4A,TRHR2,TACR1B,HCRTR2,LEPR |
| Nicotine addiction | GABRA4,SLC17A6,GRIN3A,GRIA1,GABRA2,GABRB2,GRIN2B,GRIA4,GABRQ,GRIN2A |
| Retrograde endocannabinoid signaling | GNAI3,GABRR1,GNB2,PRKCG,GABRA6,ITPR1,MAPK8,GNG13,MAPK3,MAPK13 |
| GABAergic synapse | SLC38A2,PRKCB,GABRQ,GLUL,GNAO1,GNB2,GNB3,GLS,PRKACA,GAD1 |
Protein Function
GABRE has several biochemical functions, for example, GABA-A receptor activity,contributes_to benzodiazepine receptor activity,chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GABRE itself. We selected most functions GABRE had, and list some proteins which have the same functions with GABRE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inhibitory extracellular ligand-gated ion channel activity | GABRA2,GABRA4,GABRG3,GABRA5,GABRG1,GABRA6,GABRA6A,GABRA3,GABRA1,GABRB2 |
| chloride channel activity | GABRG3,CLIC3,CLCN1,TTYH3,SLC26A6,CLIC1,GABRB2,SLC26A3,CLCC1,GABRA6 |
| GABA-A receptor activity | GABRG2,GABRR1,GABRB3,GABRR2,GABRD,GABRB2,GABRA1,GABRR3,GABRB1,GABRR2A |
| contributes_to benzodiazepine receptor activity | GABRA5,GABRG3,GABRG1,GABRA6A,GABRA1 |
Interacting Protein
GABRE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABRE here. Most of them are supplied by our site. Hope this information will be useful for your research of GABRE.
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References
- Knoll, S; Furst, K; et al. E2F1 induces miR-224/452 expression to drive EMT through TXNIP downregulation. EMBO REPORTS 15:1315-1329(2014).
- Khan, MS; Zetterlund, EL; et al. Pharmacogenetics, Plasma Concentrations, Clinical Signs and EEG During Propofol Treatment. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 115:565-570(2014).
