GABRA3
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Official Full Name
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 -
Overview
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are;ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as;benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been;identified. -
Synonyms
GABRA3;gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3;gamma-aminobutyric acid receptor subunit alpha-3;GABA(A) receptor subunit alpha 3;GABR A3;GABRA 3;Gamma aminobutyric acid (GABA) A receptor alpha 3;Gamma aminobutyric acid A receptor alpha 3;Gamma aminobutyric acid receptor subunit alpha 3;MGC33793;OTTMUSP00000019432;OTTMUSP00000019433;GABA(A) receptor subunit alpha-3;Gabra-3
Recombinant Proteins
- Human
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GABRA3-13093H | Recombinant Human GABRA3, GST-tagged | E.coli | Human | GST | 24-282a.a. | |
| GABRA3-444H | Recombinant Human GABRA3 | Mammalian Cell | Human | His |
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| GABRA3-6065HCL | Recombinant Human GABRA3 293 Cell Lysate | HEK293 | Human | Non |
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| GABRA3-1543H | Recombinant Human GABRA3 Protein, His-tagged | E.coli | Human | His | Gly30-Gly276 |
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| GABRA3-2994H | Recombinant Human GABRA3 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| GABRA3-2994H-B | Recombinant Human GABRA3 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| GABRA3-4637H | Recombinant Human GABRA3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GABRA3-5187HF | Recombinant Full Length Human GABRA3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 30-492 amino acids |
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Involved Pathway
GABRA3 involved in several pathways and played different roles in them. We selected most pathways GABRA3 participated on our site, such as Neuroactive ligand-receptor interaction,Retrograde endocannabinoid signaling,GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABRA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | F2RL1.1,PTGER4B,LPAR6,PRP2,CHRNA5,TACR3,PTGER1C,P2RY13,TAAR7A,TAAR14A |
| Nicotine addiction | GRIN1,GRIN2B,GRIA4,GABRG1,GABRA2,GABRA1,GABRA6,GABRR1,GABRQ,SLC17A8 |
| Retrograde endocannabinoid signaling | PRKCB,GNAI3,MAPK10,PRKACA,GNG11,GABRG3,MAPK12,ITPR3,GNG5,FAAH |
| GABAergic synapse | GABRA6,GNG4,GABRR2,GAD1,PRKACB,SLC6A13,GNGT1,SLC12A5,PRKACG,NSF |
Protein Function
GABRA3 has several biochemical functions, for example, contributes_to GABA-A receptor activity,benzodiazepine receptor activity,chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GABRA3 itself. We selected most functions GABRA3 had, and list some proteins which have the same functions with GABRA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| benzodiazepine receptor activity | GABRG2,GABRA2,GABRA4,TSPO,GABRA6 |
| inhibitory extracellular ligand-gated ion channel activity | GABRG1,GABRA6,GABRA1,GABRG2,GABRA4,GABRE,GABRG3,GABRA6A,GABRA5,GABRB2 |
| contributes_to GABA-A receptor activity | GABRQ,GABRA6,GABRA5,GABRG3,GABRG2,GABRA2,GABRA4,GABRA6A,GABRP,GABRR3A |
| chloride channel activity | CLCC1,CLICA,CLCN4,SLC26A5,CLCA5,CLIC2,SLC26A4,CLIC5,GABRA6,CLCA4 |
Interacting Protein
GABRA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABRA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GABRA3.
PIK3R1;UGT2B7;SDCBP2
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References
- Kawasaki, K; Kondoh, E; et al. Reliable pre-eclampsia pathways based on multiple independent microarray data sets. MOLECULAR HUMAN REPRODUCTION 21:217-224(2015).
- Loriot, A; Van Tongelen, A; et al. A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors. EPIGENETICS 9:1163-1171(2014).
