Fkrp
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Official Full Name
FKRP fukutin related protein [ Homo sapiens (human) ] -
Overview
This gene encodes a protein which is targeted to the medial Golgi apparatus and is necessary for posttranslational modification of dystroglycan. Mutations in this gene have been associated with congenital muscular dystrophy, mental retardation, and cerebellar cysts. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. -
Synonyms
Fkrp;FKRP_HUMAN;FLJ12576;Fukutin related protein;Fukutin-related protein;LGMD2I;MDC1C;MGC2991
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- Mammalian cells
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
- Flag
Involved Pathway
Fkrp involved in several pathways and played different roles in them. We selected most pathways Fkrp participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Fkrp were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
Fkrp has several biochemical functions, for example, transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fkrp itself. We selected most functions Fkrp had, and list some proteins which have the same functions with Fkrp. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transferase activity | CD38,LPCAT3,UGT2B5,AGXTB,FUT9A,NR5A1B,EHMT1B,SPTLC2A,GGACT.3,SULT1ST2 |
Interacting Protein
Fkrp has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fkrp here. Most of them are supplied by our site. Hope this information will be useful for your research of Fkrp.
Resources
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References
- Jimenez-Mallebrera, C; Torelli, S; et al. A Comparative Study of alpha-Dystroglycan Glycosylation in Dystroglycanopathies Suggests that the Hypoglycosylation of alpha-Dystroglycan Does Not Consistently Correlate with Clinical Severity. BRAIN PATHOLOGY 19:596-611(2009).
- Moore, CJ; Goh, HT; et al. Genes required for functional glycosylation of dystroglycan are conserved in zebrafish. GENOMICS 92:159-167(2008).
