Fibrin
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Official Full Name
Fibrin -
Overview
Fibrin (also called Factor Ia) is a fibrous, non-globular protein involved in the clotting of blood. It is formed by the action of the protease thrombin on fibrinogen which causes the latter to polymerize. The polymerized fibrin together with platelets forms a hemostatic plug or clot over a wound site.<br/>When the lining of a blood vessel is broken, platelets are attracted forming a platelet plug. These platelets express thrombin receptors on their surfaces that bind serum thrombin molecules[1] which in turn convert soluble fibrinogen in the serum into fibrin at the wound site. Fibrin forms long strands of tough insoluble protein that are laid down and are bound to the platelets. Factor XIII completes the cross-linking of fibrin so that it hardens and contracts. The cross-linked fibrin forms a mesh overlying the platelet plug that completes the clot. -
Synonyms
Factor Ia;Fibrin
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Fibrin-001H | Native Human Fibrin Protein | Human Plasma | Human | Non |
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Involved Pathway
Fibrin involved in several pathways and played different roles in them. We selected most pathways Fibrin participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Fibrin were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
Fibrin has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Fibrin itself. We selected most functions Fibrin had, and list some proteins which have the same functions with Fibrin. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
Fibrin has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fibrin here. Most of them are supplied by our site. Hope this information will be useful for your research of Fibrin.
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References
- Muthard, RW; Welsh, JD; et al. Fibrin, gamma '-Fibrinogen, and Transclot Pressure Gradient Control Hemostatic Clot Growth During Human Blood Flow Over a Collagen/Tissue Factor Wound. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:645-654(2015).
- Chaves, EGA; Weber, SS; et al. Analysis of Paracoccidioides secreted proteins reveals fructose 1,6-bisphosphate aldolase as a plasminogen-binding protein. BMC MICROBIOLOGY 15:-(2015).
