Fgd2
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Official Full Name
FYVE, RhoGEF and PH domain containing 2
Recombinant Proteins
- Rhesus macaque
- Mouse
- Human
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
Fgd2 involved in several pathways and played different roles in them. We selected most pathways Fgd2 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE,G alpha (12/13) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fgd2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR downstream signaling | FPR-RS4,ADM,RAMP1,ARHGEF18A,KISS1,ADCYAP1B,CALCRL,PENKB,RLN3,PNOCB |
| Rho GTPase cycle | ARHGAP24,RALBP1,CHN1,RHOF,ARHGAP15,GDI2,RHOT1A,ARHGAP12,ARHGAP18,AKAP13 |
| NRAGE signals death through JNK | ARHGEF18A,ECT2,ARHGAP4,ARHGEF16,ARHGEF9,FGD4,FGD4A,ARHGEF1A,DCLRE1B,TIAM2 |
| Cell death signalling via NRAGE, NRIF and NADE | ITGB3BP,ARHGEF17,CASP2,KALRNB,TIAM2,TRIO,ARHGAP4,NET1,FGD4,ARHGAP4A |
| Signaling by Rho GTPases | ARHGEF17,ARHGAP10,WIPF3,CIT,NCKIPSD,RHOT2,CHN1,RHPN1,ARHGAP11A,DEPDC7 |
| G alpha (12/13) signalling events | ECT2,ARHGEF3,RHOGA,ARHGEF1A,ADRA1D,ARHGAP4A,RHOC,DCLRE1B,NET1,FGD4A |
| Signal Transduction | SKI,OR7D2,BCO2,HECW1,PAG1,STARD13,GDI2,EMR2,DNAL4B,HEYL |
| Signaling by GPCR | CNR2,S1PR5B,EDNRAB,PTHRP2,OXGR1,GPR31,EMR1,PTH2,GPR55,EMR2 |
Protein Function
Fgd2 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity,guanyl-nucleotide exchange factor activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Fgd2 itself. We selected most functions Fgd2 had, and list some proteins which have the same functions with Fgd2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LRRK2,MARK2,MC3R,MECOM,IL6,TRPM6,EPN3,HSP90AA1.1,ESRP1,REEP6 |
| Rho guanyl-nucleotide exchange factor activity | PLEKHG3,C3A.1,ARHGEF17,PLEKHG5,FGD4,PREX1,PLEKHG4,ARHGEF19,ARHGEF1B,ABR |
| small GTPase binding | FGD3,FGD4,ERRFI1,TSC2,GDI2,FLNA,RNF152,PEX5L,RCC2,PEX5 |
| metal ion binding | ZC3H13,COL18A1,EGR2,KLF3,COL5A1,ATP8B5,ELOF1,PRKRIR,PVALB6,GTF3A |
| guanyl-nucleotide exchange factor activity | RALGPS1,ITSN1,TIAM2,RASGEF1BB,ARHGEF39,FAM116B,DENND1C,TAGAP,RALGDS,ARFGEF1 |
Interacting Protein
Fgd2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fgd2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fgd2.
KLHL12;TMEM239;RNPS1
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References
- Hasler, R; Kerick, M; et al. Alterations of pre-mRNA splicing in human inflammatory bowel disease. EUROPEAN JOURNAL OF CELL BIOLOGY 90:603-611(2011).
- Cerda-Reverter, JM; Agulleiro, MJ; et al. Involvement of melanocortin receptor accessory proteins (MRAPs) in the function of melanocortin receptors. GENERAL AND COMPARATIVE ENDOCRINOLOGY 188:133-136(2013).
