FXYD7
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Official Full Name
FXYD domain containing ion transport regulator 7 -
Overview
This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. -
Synonyms
FXYD7;FXYD domain containing ion transport regulator 7;FXYD domain-containing ion transport regulator 7;FLJ25096
Recombinant Proteins
- Human
- Rat
- Mouse
- Bovine
- Mus musculus
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
FXYD7 involved in several pathways and played different roles in them. We selected most pathways FXYD7 participated on our site, such as Ion channel transport,Ion transport by P-type ATPases,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with FXYD7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transmembrane transport of small molecules | SLC6A20B,SLC4A2A,SLC7A10,ABCA4A,SLC5A2,ATP1A1A.2,SLC4A8,SLC30A6,TPCN1,TRPM4A |
| Ion transport by P-type ATPases | FXYD6,ATP13A5,ATP10A,ATP1A1A.3,ATP2C2,ATP2C1,ATP2B3A,ATP13A1,FXYD3,ATP13A |
| Ion channel transport | CLCN6,ATP6V1G3,CLIC2,ATP7B,ATP1A1A.4,CCC2,TTYH3,CLCA1,FXYD6,BEST3 |
Protein Function
FXYD7 has several biochemical functions, for example, ATPase binding,ion channel activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FXYD7 itself. We selected most functions FXYD7 had, and list some proteins which have the same functions with FXYD7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sodium channel regulator activity | SCLT1,FGF12,FXYD2,AGT,SCN2B,FXYD4,SGK2B,FXYD1,SCN3B,FXYD3 |
| ion channel activity | SCN4AB,KCNH1A,TRPM4A,TPC3,ITPR3,CNGA5,CNGA4,CACNA1BA,ITPR1,SCN8AB |
| ATPase binding | SNTA1,ZNHIT6,CHRNA7,S100A1,ATP1B3,SLC26A9,DRD1,TOR1AIP1,PTPN3,ABCA1 |
| protein binding | EIF2B5,DNAJC27,CDH5,MYO9B,EEF1A2,KRTAP19-7,SFPI1,FNDC3B,BRSK1,NSUN4 |
Interacting Protein
FXYD7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FXYD7 here. Most of them are supplied by our site. Hope this information will be useful for your research of FXYD7.
SGTA;APPBP2
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References
- Li, BM; Hertz, L; et al. Cell-Specific mRNA Alterations in Na+, K+-ATPase alpha and beta Isoforms and FXYD in Mice Treated Chronically with Carbamazepine, an Anti-Bipolar Drug. NEUROCHEMICAL RESEARCH 38:834-841(2013).
- Moshitzky, S; Asher, C; et al. Intracellular Trafficking of FXYD1 (Phospholemman) and FXYD7 Proteins in Xenopus Oocytes and Mammalian Cells. JOURNAL OF BIOLOGICAL CHEMISTRY 287:21130-21141(2012).
