FUT6
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Official Full Name
fucosyltransferase 6 (alpha (1,3) fucosyltransferase) -
Overview
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
FUT6;fucosyltransferase 6 (alpha (1,3) fucosyltransferase);alpha-(1,3)-fucosyltransferase;alpha (1;3) fucosyltransferase;FCT3A;FLJ40754;FT1A;FucT VI;galactoside 3 L fucosyltransferase;Alpha (1,3) fucosyltransferase;EC=2.4.1.65;Fuc TVI;Fucosyltransferase 6;Fucosyltransferase VI;galactoside 3-L-fucosyltransferase;Fuc-TVI;FucT-VI
Recombinant Proteins
- Human
- Pan troglodytes
- E.coli
- E.Coli or Yeast
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- GST
- His&T7
- His
- Non
- His&GFP
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FUT6-13045H | Recombinant Human FUT6, GST-tagged | E.coli | Human | GST | 36-359a.a. | |
| FUT6-1412H | Recombinant Human FUT6 protein, His & T7-tagged | E.coli | Human | His&T7 | Arg35~Thr359 |
|
| FUT6-3289P | Recombinant Pan troglodytes (Chimpanzee) FUT6, His-tagged | E.Coli or Yeast | Pan troglodytes | His | 359 |
|
| FUT6-6113HCL | Recombinant Human FUT6 293 Cell Lysate | HEK293 | Human | Non |
|
|
| FUT6-2326H | Recombinant Human FUT6 Protein (Arg35-Thr359), N-His tagged | E.coli | Human | His | Arg35-Thr359 |
|
| FUT6-27H | Recombinant Human FUT6 Protein (AA 40-359), N-6×His/GFP tagged | HEK293 | Human | His&GFP | AA 40-359 |
|
| FUT6-4565H | Recombinant Human FUT6 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| FUT6-5184HF | Recombinant Full Length Human FUT6 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 359 amino acids |
|
| RFL13091HF | Recombinant Full Length Human Alpha-(1,3)-Fucosyltransferase 6(Fut6) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-359) |
|
Involved Pathway
FUT6 involved in several pathways and played different roles in them. We selected most pathways FUT6 participated on our site, such as Glycosphingolipid biosynthesis - lacto and neolacto series,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosphingolipid biosynthesis - lacto and neolacto series | B3GNT2,B3GALT5,FUT9,ST3GAL4,B3GNT4,B4GALT3,FUT7,FUT1,B3GNT5A,B3GNT5B |
| Metabolic pathways | SGSH,ATP5IA,G6PC2,IDO2,PNLIPRP3,GLUD1A,ASMT,HEXB,UQCRB,SPTLC1 |
Protein Function
FUT6 has several biochemical functions, for example, 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity,alpha-(1->3)-fucosyltransferase activity,fucosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FUT6 itself. We selected most functions FUT6 had, and list some proteins which have the same functions with FUT6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-(1->3)-fucosyltransferase activity | GLT8D1,POMGNT2,FUT4,FUT9,4931440L10Rik,POC1BL,B3GNT9-PS,PIGB,DPY19L4,GTDC2 |
| fucosyltransferase activity | FT2,POFUT1,FT1,DPY19L4,GALNTL4,FUT9,GLT8D1,DPY19L1,FUT9D,FUT9B |
| 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity | FUT3 |
Interacting Protein
FUT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of FUT6.
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References
- Duell, EJ; Bonet, C; et al. Variation at ABO histo-blood group and FUT loci and diffuse and intestinal gastric cancer risk in a European population. INTERNATIONAL JOURNAL OF CANCER 136:880-893(2015).
- Groux-Degroote, S; Wavelet, C; et al. B4GALNT2 gene expression controls the biosynthesis of Sd(a) and sialyl Lewis X antigens in healthy and cancer human gastrointestinal tract. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 53:442-449(2014).
