FRAT2
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Official Full Name
frequently rearranged in advanced T-cell lymphomas 2 -
Overview
The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. -
Synonyms
FRAT2;frequently rearranged in advanced T-cell lymphomas 2;GSK-3-binding protein FRAT2;GSK 3 binding protein FRAT2;GSK-3 binding protein FRAT2;FRAT-2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FRAT2-6031M | Recombinant Mouse FRAT2 Protein | Mammalian Cell | Mouse | His |
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| FRAT2-666HCL | Recombinant Human FRAT2 cell lysate | Human | Non |
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| FRAT2-3354M | Recombinant Mouse FRAT2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FRAT2-3354M-B | Recombinant Mouse FRAT2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FRAT2-4491H | Recombinant Human FRAT2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FRAT2-5144HF | Recombinant Full Length Human FRAT2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 233 amino acids |
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Involved Pathway
FRAT2 involved in several pathways and played different roles in them. We selected most pathways FRAT2 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FRAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | PRKCG,AXIN1,DKK4,PPP3R1,CXXC4,FBXW11,VANGL2,WNT9A,FZD8B,TBL1X |
Protein Function
FRAT2 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by FRAT2 itself. We selected most functions FRAT2 had, and list some proteins which have the same functions with FRAT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | STPG1,FAM43B,ETV3,CATSPERG1,TMEM119B,VWC2,GM239,M1AP,ASB10,HEATR7B1 |
Interacting Protein
FRAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FRAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FRAT2.
BUB1;EGFR;NRAS;KRAS;ERBB2;MCC;CTNNA1;MLH1;PTPN12;CDKN2A;MLH3;GSK3B
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References
- Walf-Vorderwulbecke, V; de Boer, J; et al. Frat2 mediates the oncogenic activation of Rac by MLL fusions. BLOOD 120:4819-4828(2012).
- Lachenmayer, A; Alsinet, C; et al. Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib. CLINICAL CANCER RESEARCH 18:4997-5007(2012).
