FPGS
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Official Full Name
folylpolyglutamate synthase -
Overview
This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms. -
Synonyms
FPGS;folylpolyglutamate synthase;folylpolyglutamate synthase, mitochondrial;tetrahydrofolate synthase;folylpoly-gamma-glutamate synthetase;tetrahydrofolylpolyglutamate synthase
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FPGS-12608Z | Recombinant Zebrafish FPGS | Mammalian Cell | Zebrafish | His |
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| FPGS-6020M | Recombinant Mouse FPGS Protein | Mammalian Cell | Mouse | His |
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| FPGS-3345M | Recombinant Mouse FPGS Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FPGS-3345M-B | Recombinant Mouse FPGS Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FPGS-4483H | Recombinant Human FPGS Protein, GST-tagged | Wheat Germ | Human | GST |
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| Fpgs-739M | Recombinant Mouse Fpgs Protein, His-tagged | E.coli | Mouse | His | Thr210~Cys439 |
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Involved Pathway
FPGS involved in several pathways and played different roles in them. We selected most pathways FPGS participated on our site, such as Folate biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FPGS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Folate biosynthesis | QDPRA,ALPPL2,ALPI,SPR,ALPI.2,SPRA,GCH1,ALPP,MOCS1,ALP3 |
| Metabolic pathways | MTMR1,NDUFB1,ACADL,GGT1,ATP6V1G2,POLR1D,LSS,CYP4A12A,MVDA,TRIT1 |
Protein Function
FPGS has several biochemical functions, for example, ATP binding,ligase activity,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FPGS itself. We selected most functions FPGS had, and list some proteins which have the same functions with FPGS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CDC34A,ATP9B,ANKK1,MKI67,RLN1,WNK2,MOV10B.2,DGKG,SPEG,BMPR1B |
| ligase activity | EGR2,RCHY1,TRIM71,TRIM11,RTCB,MARCH8,PARK2,RC3H2,TRIP12,RNF25 |
| nucleotide binding | ELAVL1,MAP4K6,SRSF3,HSPA4A,HIPK3B,RAP2AB,ACTR1,BAT1,EPHB2B,MRPL23 |
Interacting Protein
FPGS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FPGS here. Most of them are supplied by our site. Hope this information will be useful for your research of FPGS.
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References
- Li, L; Hill-Skinner, S; et al. The maize brown midrib4 (bm4) gene encodes a functional folylpolyglutamate synthase. PLANT JOURNAL 81:493-504(2015).
- Nowak, D; Liem, NLM; et al. Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance. EXPERIMENTAL HEMATOLOGY 43:32-43(2015).
