FOXP2
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Official Full Name
forkhead box P2 -
Overview
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010] -
Synonyms
FOXP2;forkhead box P2;SPCH1;CAGH44;TNRC10;forkhead box protein P2;CAG repeat protein 44;trinucleotide repeat containing 10;forkhead/winged-helix transcription factor;trinucleotide repeat-containing gene 10 protein
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- E. coli
- HEK293
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- His&GST
- His&Fc&Avi
- Flag
- Myc&DDK
- GST
Involved Pathway
FOXP2 involved in several pathways and played different roles in them. We selected most pathways FOXP2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
FOXP2 has several biochemical functions, for example, DNA binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXP2 itself. We selected most functions FOXP2 had, and list some proteins which have the same functions with FOXP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZNF830,UHMK1,UBL7,FEN1,HNRNPH1,PRADC1,FADD,AGTR2,NAA38,ATXN2 |
| DNA binding | AIFM2,ZFP687,NKX2.4A,TFB1M,GEN1,ZFP74,TIGD5,HIST2H2AC,MBD1B,ZBTB18 |
| sequence-specific DNA binding | MNX1,ZNF394,ZSCAN4,TCF3A,CHES1,GZF1,HHEX,TP63,THRAA,ZNF396 |
| protein homodimerization activity | PDGFC,ARID3A,MCL1A,USH1G,HHEX,GRPEL2,UGT1A4,TG,VPS24,SUMF1 |
| metal ion binding | ZNF397,PRDM10,ZFP598,TRIM105,GNAI2,ZNF598,ZNF74,VEZF1B,ATP1A1A.1,GUCA1G |
| transcription factor activity, sequence-specific DNA binding | REL,SP3A,ZKSCAN4,SREBF1,HSF5,NFIL3-3,GATAD2AB,SPI1A,FOXL1,TEFB |
Interacting Protein
FOXP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXP2.
arre2_element_mouse_il2_promoter;SDCBP;CCNC;CTBP2;AES;CTBP1;PIN1
Resources
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References
- Renier, N; Wu, ZH; et al. iDISCO: A Simple, RapidMethod to Immunolabel Large Tissue Samples for Volume Imaging. CELL 159:896-910(2014).
- Iwai, L; Ohashi, Y; et al. FoxP2 is a Parvocellular-Specific Transcription Factor in the Visual Thalamus of Monkeys and Ferrets. CEREBRAL CORTEX 23:2204-2212(2013).
