FOXN1
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Official Full Name
forkhead box N1 -
Overview
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5 UTR of this gene has been observed. [provided by RefSeq, Jul 2008] -
Synonyms
FOXN1;forkhead box N1;WHN;RONU;FKHL20;forkhead box protein N1;Rowett nude;winged helix nude;winged-helix nude;winged-helix transcription factor nude
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FOXN1-11853Z | Recombinant Zebrafish FOXN1 | Mammalian Cell | Zebrafish | His |
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| FOXN1-4467H | Recombinant Human FOXN1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FOXN1-5099HF | Recombinant Full Length Human FOXN1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 648 amino acids |
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| FOXN1-5644H | Recombinant Human FOXN1 protein, His&Myc-tagged | in vitro E.coli expression system | Human | N-His&C-Myc | 1-648aa |
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Involved Pathway
FOXN1 involved in several pathways and played different roles in them. We selected most pathways FOXN1 participated on our site, such as canonical wnt - zebrafish, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| canonical wnt - zebrafish | ENG1A,EVE1,SOX9B,RARGA,VOX,RHOUA,SMARCA4A,CAMK1GA,IRX3A,ENG2A |
Protein Function
FOXN1 has several biochemical functions, for example, DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXN1 itself. We selected most functions FOXN1 had, and list some proteins which have the same functions with FOXN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | NR4A2A,ARXA,HIVEP3,DMRT3,NKX2.3,CSRNP1,SOX13,HNF4G,POU2F1A,GSX1 |
| transcription factor activity, sequence-specific DNA binding | ZNF215,PFDN1,SMAD3,HOXB8A,MTA1,AHCTF1,FOXG1,FOSL2,BLF,TBX5B |
| transcription regulatory region sequence-specific DNA binding | BACH1B,ARNTL,NFE2L1A,EGR1,NR5A2,SOX4,MKL1,SOX2,POU2F1,NFE2L2B |
| DNA binding | MYCA,HER4.3,ZNF75A,DBX1B,ZHX1,ZBED5,DNASE1L3,ZIM3,BSX,TOP3A |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | CC2D1B,NFIXB,FOXK1,HOXA13A,FOXC1B,JUNBA,FOXC1,TFAP2D,ELF3,FOXP3A |
Interacting Protein
FOXN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXN1.
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References
- Zhang, H; Zhang, P; et al. In vitro study of the effect of small interfering ribonucleic acid on the expression of FOXN1 and B cell-attracting chemokine 1 in thymoma cell lines. THORACIC CANCER 6:172-179(2015).
- Eschbach, RS; Fendler, WP; et al. Correlation of Perfusion MRI and F-18-FDG PET Imaging Biomarkers for Monitoring Regorafenib Therapy in Experimental Colon Carcinomas with Immunohistochemical Validation. PLOS ONE 10:-(2015).
