FOXE3
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Official Full Name
forkhead box E3 -
Overview
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia. -
Synonyms
FOXE3;forkhead box E3;FKHL12;forkhead box protein E3;FREAC8;Forkhead related protein FKHL12;Drosphilia Forkhead Homolog Like 12;FKHL 12;Forkhead BoxE3;Forkhead Related Activator 8;FOXE3 forkhead box E3;FREAC 8;FREAC-8;forkhead-related protein FKHL12;forkhead, drosophila, homolog-like 12;forkhead-related transcription factor 8
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FOXE3-4890Z | Recombinant Zebrafish FOXE3 | Mammalian Cell | Zebrafish | His |
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| FOXE3-514H | Recombinant Human FOXE3 | Mammalian Cell | Human | His |
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| Foxe3-1517M | Recombinant Mouse Foxe3 Protein, His-tagged | E.coli | Mouse | His | Asn110-Leu288 |
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| FOXE3-2967H | Recombinant Human FOXE3 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| FOXE3-2967H-B | Recombinant Human FOXE3 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
FOXE3 involved in several pathways and played different roles in them. We selected most pathways FOXE3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXE3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
FOXE3 has several biochemical functions, for example, DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXE3 itself. We selected most functions FOXE3 had, and list some proteins which have the same functions with FOXE3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | MEOX2,NR5A1B,ZFP551,CHES1,HLF,PAX8,LHX1,TP73,NR2F1B,SMAD7 |
| sequence-specific DNA binding | FOXI3B,NFE2L1A,ZSCAN12,FOXC2,SP1,HOXC13B,ZNF192,IRX2A,HOXB8,HOXB13A |
| DNA binding | ZFP64,HMGXB4,SIX6A,ZBTB16,HIST1H2BJ,HOXC3A,SUPV3L1,LHFP,AHRRB,HOXD13 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | PHB,PAX6,ELF5,AHR2,ZNF174,OVOL2,EOMESA,FLI1B,RELB,TFDP2 |
Interacting Protein
FOXE3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXE3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXE3.
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References
- Terrell, AM; Anand, D; et al. Molecular characterization of mouse lens epithelial cell lines and their suitability to study RNA granules and cataract associated genes. EXPERIMENTAL EYE RESEARCH 131:42-55(2015).
- Anchan, RM; Lachke, SA; et al. Pax6- and Six3-Mediated Induction of Lens Cell Fate in Mouse and Human ES Cells. PLOS ONE 9:-(2014).
