FOXE1
-
Official Full Name
forkhead box E1 (thyroid transcription factor 2) -
Overview
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I. [provided by RefSeq, Jul 2008] -
Synonyms
FOXE1;forkhead box E1 (thyroid transcription factor 2);TTF2;FOXE2;HFKH4;HFKL5;TITF2;TTF-2;FKHL15;forkhead box protein E1;forkhead box E2;forkhead box protein E2;HNF-3/fork head-like protein 5;thyroid transcription factor 2;forkhead-related protein FKHL15;forkhead, drosophila, homolog-like 15
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FOXE1-5986M | Recombinant Mouse FOXE1 Protein | Mammalian Cell | Mouse | His |
|
|
| Foxe1-1516M | Recombinant Mouse Foxe1 Protein, His-tagged | E.coli | Mouse | His | Asn127-Met371 |
|
| FOXE1-3321M | Recombinant Mouse FOXE1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| FOXE1-3321M-B | Recombinant Mouse FOXE1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
||
| FOXE1-4447H | Recombinant Human FOXE1 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| FOXE1-5059HF | Recombinant Full Length Human FOXE1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 373 amino acids |
|
Involved Pathway
FOXE1 involved in several pathways and played different roles in them. We selected most pathways FOXE1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
FOXE1 has several biochemical functions, for example, DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXE1 itself. We selected most functions FOXE1 had, and list some proteins which have the same functions with FOXE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | TADA2B,ZEB1,SCMH1,IRF1B,BLZF1,KLF3,SNAPC4,CNOT7,HEY1,AATF |
| DNA binding | KLF14,RELA,HELT,PSMC3IP,ZNF287,CDAN1,DBN1,TBX1,MXD3,MTERFD1 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | TFDP3,TFAP2E,RUNX3,TAL1,NPAS1,ZSCAN5A,CC2D1B,BETA3,SIM1B,SOX30 |
| sequence-specific DNA binding | LHX8A,MKXA,HSFX1,HOXC12A,ATF7A,ATF5A,NKX2-1,HMX3,CREBL2,HOXC9 |
Interacting Protein
FOXE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXE1.
Resources
Related Services
Related Products
References
- Figlioli, G; Chen, BW; et al. Novel genetic variants in differentiated thyroid cancer and assessment of the cumulative risk. SCIENTIFIC REPORTS 5:-(2015).
- Pereda, CM; Lesueur, F; et al. Common variants at the 9q22.33, 14q13.3 and ATM loci, and risk of differentiated thyroid cancer in the Cuban population. BMC GENETICS 16:-(2015).
