FOSL2
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Official Full Name
FOS-like antigen 2 -
Overview
FRA-2 has homologous sequence with c-Fos, FRA-1, and FOS B. It forms heterodimers with c-Jun that recognize specific DNA sequences, such as the binding site for transcription factor AP-1. -
Synonyms
FOSL2;FOS-like antigen 2;fos-related antigen 2;FLJ23306;FRA2;FRA-2
Recombinant Proteins
- Rhesus macaque
- Chicken
- Zebrafish
- Mouse
- Human
- Mammalian Cell
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- His&SUMO
- GST
Involved Pathway
FOSL2 involved in several pathways and played different roles in them. We selected most pathways FOSL2 participated on our site, such as Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOSL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | TNFRSF11A,NFKB2,BTK,NFKBIA,MAP3K7,TGFB2,TYK2,IL1A,LILRB5,TGFBR1 |
Protein Function
FOSL2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOSL2 itself. We selected most functions FOSL2 had, and list some proteins which have the same functions with FOSL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | EIF4EBP2,AIMP1,MTMR9,PDGFRB,PITX2,CRHR2,ANKHD1,REEP1,PPP1R13L,ZFPM2A |
| transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | RBPJL,FOSB,FOS,ARNTL2,SNAI3,ATF3,BATF,JDP2,TFAP2A,RBPJA |
| chromatin binding | NCAPD3,APBB1,RERE,TOX2,KAT2A,NFATC3,SHMT2,HMGXB4A,TAL1,SP140L |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | MYC,EN1,RFX1,ZFP746,ZNF264,MYBL1,DPF2,NOBOX,H2AFZ,HHEX |
| transcription factor activity, sequence-specific DNA binding | ATF5,MYT1LA,PAX8,ZNF79,FOXC1B,ZFP260,FOXN2B,TSC22D4,KDM5A,IRF4 |
Interacting Protein
FOSL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOSL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOSL2.
JUN;JUNB;JUND;DDIT3;CREB5;TRAF1
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References
- Gast, H; Muller, A; et al. CD40 activation induces NREM sleep and modulates genes associated with sleep homeostasis. BRAIN BEHAVIOR AND IMMUNITY 27:133-144(2013).
- Doucet, JP; Nakabeppu, Y; et al. Chronic alterations in dopaminergic neurotransmission produce a persistent elevation of Delta FosB-like protein(s) in both the rodent and primate striatum. EUROPEAN JOURNAL OF NEUROSCIENCE 8:365-381(1996).
- SHARP, FR; SAGAR, SM; et al. C-FOS MESSENGER-RNA, FOS, AND FOS-RELATED ANTIGEN INDUCTION BY HYPERTONIC SALINE AND STRESS. JOURNAL OF NEUROSCIENCE 11:2321-2331(1991).
