FMO2
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Official Full Name
flavin containing monooxygenase 2 (non-functional) -
Overview
The flavin-containing monooxygenases are NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics. In most mammals, there is a flavin-containing monooxygenase that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, in humans, this enzyme is truncated and is probably rapidly degraded. The protein encoded by this gene represents the truncated form and apparently has no catalytic activity. A functional allele found in African Americans has been reported, but no sequence evidence has been deposited to support the finding. This gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1. -
Synonyms
FMO2;flavin containing monooxygenase 2 (non-functional);flavin containing monooxygenase 2;dimethylaniline monooxygenase [N-oxide-forming] 2;MGC28212;OTTMUSP00000028687;2310008D08Rik;2310042I22Rik;AW107733;Dimethylaniline monooxygenase [N oxide forming] 2;Dimethylaniline oxidase 2;Flavin containing monooxygenase 2 (non functional);FLJ40826;FMO 1B1;FMO 2;FMO;FMO pulmonary;FMO1B1;OTTMUSP00000028686;Pulmonary flavin containing monooxygenase 2;FMO, pulmonary;pulmonary flavin-containing monooxygenase 2
Recombinant Proteins
- Rhesus macaque
- Mouse
- Human
- Rat
- Mammalian Cell
- HEK293
- E.coli
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
FMO2 involved in several pathways and played different roles in them. We selected most pathways FMO2 participated on our site, such as Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with FMO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Drug metabolism - cytochrome P | GSTM,UGT1A1,GSTA,GSTA4,ALDH1A3,GSTM7,FMO5,GSTP2,AOX4,UGT1A9 |
Protein Function
FMO2 has several biochemical functions, for example, N,N-dimethylaniline monooxygenase activity,NADP binding,flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FMO2 itself. We selected most functions FMO2 had, and list some proteins which have the same functions with FMO2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| monooxygenase activity | CYP2C8,CYP4A14,TH2,CYP4F14,CYP2J6,CYP17A2,CYP7A1A,BCO1,CYP2C38,CYP2C55 |
| N,N-dimethylaniline monooxygenase activity | FMO5,FMO3,FMO1 |
| NADP binding | G6PD,POR,NOS3,SPR,ME1,NOX5,DPYD,CRYZL1,HMGCRA,IDH1 |
| flavin adenine dinucleotide binding | DHCR24,ACADS,DUS1L,GCDH,ACADM,NOS3,GFER,SDHA,ACOX1,DLDH |
Interacting Protein
FMO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FMO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FMO2.
q81qv1_bacan;ilvC2
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References
- Pruitt, SR; Bertoni, C; et al. Efficient and Accurate Fragmentation Methods. ACCOUNTS OF CHEMICAL RESEARCH 47:2786-2794(2014).
- Kitsukawa, M; Tsuchiyama, H; et al. Immunosuppressive potential of bardoxolone methyl using a modified murine local lymph node assay (LLNA). JOURNAL OF TOXICOLOGICAL SCIENCES 39:545-550(2014).
