FMNL3
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Official Full Name
formin-like 3 -
Overview
The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. -
Synonyms
FMNL3;formin-like 3;formin-like protein 3;DKFZp762B245;MGC45819;WBP3;WW domain binding protein 3;WW domain-binding protein 3;formin homology 2 domain-containing protein 3;FHOD3;WBP-3;FLJ45265
Recombinant Proteins
- Mouse
- Human
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FMNL3-5936M | Recombinant Mouse FMNL3 Protein | Mammalian Cells | Mouse | His |
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| FMNL3-659HCL | Recombinant Human FMNL3 cell lysate | Human | Non |
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| FMNL3-2435H | Recombinant Human FMNL3 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| Fmnl3-3052M | Recombinant Mouse Fmnl3 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| FMNL3-3288M | Recombinant Mouse FMNL3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FMNL3-3288M-B | Recombinant Mouse FMNL3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FMNL3-4391H | Recombinant Human FMNL3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FMNL3-4986HF | Recombinant Full Length Human FMNL3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 347 amino acids |
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Involved Pathway
FMNL3 involved in several pathways and played different roles in them. We selected most pathways FMNL3 participated on our site, such as Downregulation of ERBB2:ERBB3 signaling,Endocytosis,ErbB2/ErbB3 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with FMNL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Internalization of ErbB1 | RNF103-CHMP3,ZFYVE28,STAMBP,SPRY2 |
| Signaling by Wnt | BCL9L,SOX7,ROR1,RYK,SRY,PRICKLE1B,GPR177,TLE3B,PRICKLE1,WIF1 |
| Signaling by ERBB2 | CUL5A |
| Regulation of FZD by ubiquitination | RSPO4,ZNRF3,RSPO3,LGR4,LGR5,RSPO2,RSPO1,RNF43,LGR6 |
| Endocytosis | LDLRAP1A,PRKCI,EHD1B,IST1,SNX1A,DNM2,CSF1R,MVB12B,CYTH4B,SNX6 |
| ErbB2/ErbB3 signaling events | RNF41,DOCK7,CHRNE,CHRNA1 |
| Downregulation of ERBB2:ERBB3 signaling | NRG2A,RNF41 |
| Signal Transduction | RGS21,CCL35.2,HECW1B,ARHGAP9,PDK3,GPR31B,SHB,IFT122,KIF14,TAAR1 |
Protein Function
FMNL3 has several biochemical functions, for example, SH3 domain binding,cysteine-type endopeptidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FMNL3 itself. We selected most functions FMNL3 had, and list some proteins which have the same functions with FMNL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | SH3BP1,DNAJC6,PDCD6IP,INPPL1,REPS1,GPX1,CCDC6,GRIK5,QKI,AFAP1L2 |
| ubiquitin-specific protease activity | USP2A,UCHL1,OTUD5B,ZRANB1B,USP13,USP30,OTUB1A,OTUB1,USP17L2,BAP1 |
| cysteine-type endopeptidase activity | USP17L2,CTLA2B,USP6,USP5,CTS7,CTSSB.1,UCHL1,USP37,ESPL1,CTSLA |
| protein binding | CENPL,HBP1,PLXNB2,VGLL2,CASP10,PBXIP1,PDZK1,MKL1,E2F8,MAPK8 |
Interacting Protein
FMNL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FMNL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FMNL3.
Dlg4;PRPF40A
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References
- Gauvin, TJ; Young, LE; et al. The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion. MOLECULAR BIOLOGY OF THE CELL 26:467-477(2015).
- Wakayama, Y; Fukuhara, S; et al. Cdc42 Mediates Bmp-Induced Sprouting Angiogenesis through Fmnl3-Driven Assembly of Endothelial Filopodia in Zebrafish. DEVELOPMENTAL CELL 32:109-122(2015).
