FLNB
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Official Full Name
filamin B, beta -
Overview
This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. -
Synonyms
FLNB;filamin B, beta;filamin B, beta (actin binding protein 278) , FLN1L, Larsen syndrome 1 (autosomal dominant) , LRS1;filamin-B;ABP 278;actin binding protein 278;FH1;TABP;TAP;ABP 280 homolog;ABP278;Actin binding like protein;AOI;Beta filamin;DKFZp686A1668;DKFZp686O033;Filamin 1 actin binding protein 280 like;Filamin 3;Filamin B;Filamin B beta actin binding protein 278;Filamin homolog 1;FLN B;FLN1L;FLN3;LRS1;SCT;Thyroid autoantigen;Truncated ABP;Truncated actin binding protein;filamin-3;beta-filamin;ABP-280 homolog;actin-binding-like protein;Larsen syndrome 1 (autosomal dominant);FLN-B;ABP-278;ABP-280
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FLNB-1387H | Recombinant Human FLNB protein, His-tagged | E.coli | Human | His | Gly1175~Val1457 |
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| FLNB-1388H | Recombinant Human FLNB protein, His & T7-tagged | E.coli | Human | His&T7 | Met1~Phe237 |
|
| FLNB-2227C | Recombinant Chicken FLNB | Mammalian Cell | Chicken | His |
|
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| FLNB-1389H | Recombinant Human FLNB protein, His-tagged | E.coli | Human | His | Ala2061~Met2193 |
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| FLNB-4358H | Recombinant Human FLNB Protein, GST-tagged | Wheat Germ | Human | GST |
|
Involved Pathway
FLNB involved in several pathways and played different roles in them. We selected most pathways FLNB participated on our site, such as MAPK signaling pathway,Focal adhesion,Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLNB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | PTK2,ITGB1,PRKCBB,PDGFD,COL6A6,MYLPFB,PTENA,CAV2,RAC1B,VAV3 |
| MAPK signaling pathway | MAPK8A,TGFBR1,TGFB1,HRASA,FGF10,RELB,MAPK7,RAC1A,CACNB3A,MAP4K4 |
| Salmonella infection | ACTB,IFNGR1,ARPC5LB,RHOGD,TLR4BB,RHOGC,PFN2,MAPK11,NOS2A,ARPC5LA |
Protein Function
FLNB has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by FLNB itself. We selected most functions FLNB had, and list some proteins which have the same functions with FLNB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
FLNB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLNB here. Most of them are supplied by our site. Hope this information will be useful for your research of FLNB.
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References
- Cartault, F; Munier, P; et al. Expanding the clinical spectrum of B4GALT7 deficiency: homozygous p.R270C mutation with founder effect causes Larsen of Reunion Island syndrome. EUROPEAN JOURNAL OF HUMAN GENETICS 23:49-53(2015).
- Coumans, JVF; Gau, D; et al. Profilin-1 Overexpression in MDA-MB-231 Breast Cancer Cells Is Associated with Alterations in Proteomics Biomarkers of Cell Proliferation, Survival, and Motility as Revealed by Global Proteomics Analyses. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY 18:778-791(2014).
