FKTN
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Official Full Name
fukutin -
Overview
The protein encoded by this gene is a putative transmembrane protein that is localized to the cis-Golgi compartment, where it may be involved in the glycosylation of alpha-dystroglycan in skeletal muscle. The encoded protein is thought to be a glycosyltransferase and could play a role in brain development. Defects in this gene are a cause of Fukuyama-type congenital muscular dystrophy (FCMD), Walker-Warburg syndrome (WWS), limb-girdle muscular dystrophy type 2M (LGMD2M), and dilated cardiomyopathy type 1X (CMD1X). Alternatively spliced transcript variants have been found for this gene. -
Synonyms
FKTN;fukutin;FCMD, Fukuyama type congenital muscular dystrophy (fukutin);LGMD2M;CMD1X;FCMD;FKTN_HUMAN;Fukuyama type congenital muscular dystrophy protein;Fukuyama-type congenital muscular dystrophy protein;MDDGA4;MDDGB4;MDDGC4;MGC126857;MGC134944;MGC134945;MGC138243;OTTHUMP00000021841
Recombinant Proteins
- Human
- Zebrafish
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In vitro E. coli expression system
- E.coli expression system
- His
- GST
- Non
- His&Myc
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FKTN-12921H | Recombinant Human FKTN, His-tagged | E.coli | Human | His | 35-461a.a. | |
| FKTN-3822Z | Recombinant Zebrafish FKTN | Mammalian Cell | Zebrafish | His |
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| FKTN-4016H | Recombinant Human FKTN Protein, GST-tagged | Wheat Germ | Human | GST |
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| FKTN-6198HCL | Recombinant Human FKTN 293 Cell Lysate | HEK293 | Human | Non |
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| FKTN-1335C | Recombinant Cynomolgus monkey FKTN protein, His&Myc-tagged | E.coli | Cynomolgus | His&Myc | 29-461aa |
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| Fktn-3034M | Recombinant Mouse Fktn Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| Fktn-4255M | Recombinant Mouse Fktn protein, His&Myc-tagged | E.coli | Mouse | His&Myc | 29-461aa |
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| FKTN-948H | Recombinant Human FKTN Full Length Transmembrane protein, His-tagged | In vitro E. coli expression system | Human | His | Full L. 1-461aa |
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| FKTN-962H | Recombinant Human FKTN Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| RFL18545HF | Recombinant Full Length Human Fukutin(Fktn) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-461aa) |
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Involved Pathway
FKTN involved in several pathways and played different roles in them. We selected most pathways FKTN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FKTN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
FKTN has several biochemical functions, for example, transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FKTN itself. We selected most functions FKTN had, and list some proteins which have the same functions with FKTN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transferase activity | PRKG1A,PYGMB,ZDHHC18,ALPK2,GGT1A,SETDB1B,EHMT1A,FAM86,MAPK12B,ZDHHC21 |
Interacting Protein
FKTN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FKTN here. Most of them are supplied by our site. Hope this information will be useful for your research of FKTN.
Resources
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References
- Humphrey, EL; Lacey, E; et al. A new monoclonal antibody DAG-6F4 against human alpha-dystroglycan reveals reduced core protein in some, but not all, dystroglycanopathy patients. NEUROMUSCULAR DISORDERS 25:32-42(2015).
- Fortunato, MJ; Ball, CE; et al. Development of Rabbit Monoclonal Antibodies for Detection of Alpha-Dystroglycan in Normal and Dystrophic Tissue. PLOS ONE 9:-(2014).
