FIP1L1
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Official Full Name
FIP1 like 1 (S. cerevisiae) -
Overview
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3 end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
FIP1L1;FIP1 like 1 (S. cerevisiae);pre-mRNA 3-end-processing factor FIP1;DKFZp586K0717;Factor interacting with PAP;FIP1;FIP1 like 1 (S cerevisiae);FIP1 like 1;FLJ33619;hFip 1;hFip1;Pre mRNA 3 end processing factor FIP1;Rearranged in hypereosinophilia;RHE;FIP1-like 1 protein
Recombinant Proteins
- Mouse
- Human
- Mammalian Cell
- HEK293
- Insect Cell
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&GST
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FIP1L1-5894M | Recombinant Mouse FIP1L1 Protein | Mammalian Cell | Mouse | His |
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| FIP1L1-276HCL | Recombinant Human FIP1L1 lysate | HEK293 | Human | Non |
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| FIP1L1-0307H | Recombinant Human FIP1L1 Protein (S2-E594), Tag Free | Insect Cell | Human | Non | S2-E594 |
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| FIP1L1-0308H | Recombinant Human FIP1L1 Protein (S2-E594), His/GST tagged | Insect Cell | Human | His&GST | S2-E594 |
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| FIP1L1-3261M | Recombinant Mouse FIP1L1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FIP1L1-3261M-B | Recombinant Mouse FIP1L1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FIP1L1-4177H | Recombinant Human FIP1L1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FIP1L1-5113HF | Recombinant Full Length Human FIP1L1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 378 amino acids |
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Involved Pathway
FIP1L1 involved in several pathways and played different roles in them. We selected most pathways FIP1L1 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FIP1L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA surveillance pathway | PPP2CB,CPSF7,SMG7,MAGOH2,MSI2A,UPF3A,pab1,PPP2R2B,CPSF6,PPP1CB |
Protein Function
FIP1L1 has several biochemical functions, for example, poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FIP1L1 itself. We selected most functions FIP1L1 had, and list some proteins which have the same functions with FIP1L1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | KIF7,RYR1B,SESN2,PTGDR,ELP4,OTX2,SCFD1,UVRAG,LSAMP,TOP3B |
| poly(A) RNA binding | CAPRIN1,ZRANB2,PTBP1,RPS28,CCDC86,EIF4G2,AGO2,RC3H2,CSNK1E,PEF1 |
Interacting Protein
FIP1L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FIP1L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FIP1L1.
NAA10;GOLGA2;ZMYND19;CPSF4;FOS;GSK3B;WWOX;PRMT2;tdh;TFAP2C;PRMT6;ssrna_ug
Resources
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References
- Zeng, K; Li, L; et al. Newly identified phenotypes in a FIP1L1/PDGFRA-associated paediatric HES patient: thrombocytosis, mHPA, young stroke and blindness. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 29:614-616(2015).
- Chalmers, ZR; Ali, SM; et al. Comprehensive genomic profiling identifies a novel TNKS2-PDGFRA fusion that defines a myeloid neoplasm with eosinophilia that responded dramatically to imatinib therapy. BLOOD CANCER JOURNAL 5:-(2015).
