FEV
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Official Full Name
FEV (ETS oncogene family) -
Overview
This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. -
Synonyms
FEV;FEV (ETS oncogene family);FEV (fifth Ewing variant);protein FEV;Pet 1;ETS-domain transcription factor;FEV_HUMAN;Fifth Ewing variant protein;mPet1;PC12 ETS domain-containing transcription factor 1;PC12 ETS factor 1;Pet-1;HSRNAFEV
Recombinant Proteins
- Rat
- Zebrafish
- Mouse
- Human
- Mammalian Cell
- HEK293T
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
FEV involved in several pathways and played different roles in them. We selected most pathways FEV participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with FEV were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | SFPI1,MPO,HIST1H3A,FLT3,MLF1,MET,Pdgfa&Pdgfb,IGF1,CD40,ITGAM |
Protein Function
FEV has several biochemical functions, for example, RNA polymerase II transcription factor activity, sequence-specific DNA binding,double-stranded DNA binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FEV itself. We selected most functions FEV had, and list some proteins which have the same functions with FEV. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | ATF5,RBFOX2,E2F8,DR1,SAP18,SNW1,RCOR2,ZNF274,LMCD1,ZHX3 |
| transcription factor activity, sequence-specific DNA binding | FOSL2,MAFA,EOMESA,RXRB,ASCL1B,NFE2L1B,NR1H5,TGIF2,HEY2,ZNF217 |
| double-stranded DNA binding | SETMAR,HMGB2,CGGBP1,ZNF638,HNRNPDL,KIN,MTERF3,RAD51C,MTERFD2,SP8B |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXK1,FOXD4L1,FOXN1,HIF1AL2,ZSCAN5A,SOX5,JUNBB,SPI1,SOX8,ZNF174 |
| sequence-specific DNA binding | GTF2E1,HSFY1,RORC,ZNF148,FOXD4,MNX2B,FOXD2,EGR1,ISX,TLX2 |
Interacting Protein
FEV has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FEV here. Most of them are supplied by our site. Hope this information will be useful for your research of FEV.
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References
- Malo, JL; Ghezzo, H; et al. Distinct temporal patterns of immediate asthmatic reactions due to high- and low-molecular-weight agents. CLINICAL AND EXPERIMENTAL ALLERGY 42:1021-1027(2012).
- Pelaia, G; Gallelli, L; et al. Omalizumab decreases exacerbation frequency, oral intake of corticosteroids and peripheral blood eosinophils in atopic patients with uncontrolled asthma. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 49:713-721(2011).
