FES
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Official Full Name
feline sarcoma oncogene -
Overview
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms. -
Synonyms
FES;feline sarcoma oncogene;feline sarcoma (Snyder Theilen) viral (v fes)/Fujinami avian sarcoma (PRCII) viral (v fps) oncogene homolog;tyrosine-protein kinase Fes/Fps;c fes/fps protein;FPS;Oncogene FES;feline sarcoma virus;p93c-fes;proto-oncogen
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- Insect Cells
- Insect Cell
- Insect (sf21)
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- GST
- His&GST
- Non
- His&T7
- His&Fc&Avi
Involved Pathway
FES involved in several pathways and played different roles in them. We selected most pathways FES participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with FES were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | DCX,CLTC,SEMA3B,RASGEF1A,PSPN,CAP2,EPHB4B,CSK,NTNG1,SEMA4A |
Protein Function
FES has several biochemical functions, for example, ATP binding,immunoglobulin receptor binding,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FES itself. We selected most functions FES had, and list some proteins which have the same functions with FES. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CTNNAL1,METTL17,INTS3,SERTAD3,CCL18,DHX32,ATP7A,ASF1A,KRTAP12-4,SYCP1 |
| protein tyrosine kinase activity | JAK1,FYNA,TNK2B,PTK6B,KDRL,LCK,MAP2K6,CSK,FGFR1A,WEE2 |
| non-membrane spanning protein tyrosine kinase activity | JAK2A,PTK2AB,BLK,ABL2,RIPK2,TNK2B,TNK1,ABL1,PRKCD,FYNA |
| immunoglobulin receptor binding | Ighg2a,IgG3,Ighg2b,IGKC,CLEC4D,IGLC2,IGLL1,FGR,Ighg |
| microtubule binding | TRAF3IP1,KIF9,CNN3,KIF4,GAS2L2,CEP57,TXNDC3,MAP205,CRIPT,SERPINB1A |
| ATP binding | AURKA,CDC34A,MARS,FGFR1A,EPHB2,PTK2,MAP3K12,BLK,TIMM44,EPHA8 |
| phosphatidylinositol binding | WDR35,TULP2,FCHO2,SNX2,SNX19A,SNX18B,SNX32,SNX13,MITD1,SNX4 |
Interacting Protein
FES has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FES here. Most of them are supplied by our site. Hope this information will be useful for your research of FES.
EZR;TERF1;MDFI;EGFR;MET;AR;KIT;NSF
Resources
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References
- Zeng, XM; Mo, YM; et al. Identification and characterization of a periplasmic trilactone esterase, Cee, revealed unique features of ferric enterobactin acquisition in Campylobacter. MOLECULAR MICROBIOLOGY 87:594-608(2013).
- Le, HT; Gautier, V; et al. YajL, Prokaryotic Homolog of Parkinsonism-associated Protein DJ-1, Functions as a Covalent Chaperone for Thiol Proteome. JOURNAL OF BIOLOGICAL CHEMISTRY 287:5861-5870(2012).
