FERMT2

  • Official Full Name

    fermitin family member 2
  • Overview

    Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites.
  • Synonyms

    FERMT2;fermitin family member 2;MIG2;KIND2;mig-2;UNC112;PLEKHC1;UNC112B;fermitin family homolog 2;kindlin 2;kindlin-2;mitogen inducible gene 2 protein;mitogen-inducible gene 2 protein;PH domain-containing family C member 1;pleckstrin homology domain-containing family C member 1;pleckstrin homology domain containing, family C member 1;pleckstrin homology domain containing, family C (with FERM domain) member 1

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cell
  • HEK293
  • HEK293T
  • GST
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
FERMT2-12845H Recombinant Human FERMT2, GST-tagged E.coli Human GST C-term-350a.a.
FERMT2-1689R Recombinant Rhesus monkey FERMT2 Protein, His-tagged Mammalian Cell Rhesus macaque His
FERMT2-8131Z Recombinant Zebrafish FERMT2 Mammalian Cell Zebrafish His
FERMT2-6262HCL Recombinant Human FERMT2 293 Cell Lysate HEK293 Human Non
FERMT2-1511R Recombinant Rhesus Macaque FERMT2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
FERMT2-1511R-B Recombinant Rhesus Macaque FERMT2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Fermt2-2988M Recombinant Mouse Fermt2 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
FERMT2-4554H Recombinant Human FERMT2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
FERMT2-6743H Recombinant Human FERMT2 protein, His-tagged E.coli Human His 1-680a.a.

    Involved Pathway

    FERMT2 involved in several pathways and played different roles in them. We selected most pathways FERMT2 participated on our site, such as Cell junction organization,Cell-Cell communication,Cell-extracellular matrix interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with FERMT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell junction organization ITGB1B.1,CDH24,F11R.2,CDH10A,ANG,CDH12A,CDH10,JUPA,FBLIM1,CDH8
    Cell-Cell communication F11R.2,PVRL2L,CLDN16,KIRRELB,CDH2,CDH8,CDH24,FBLIM1,ANG,PLECA
    Cell-extracellular matrix interactions PARVB,RSU1,LIMS1,FBLIM1,TESK1,ITGB1B.1

    Protein Function

    FERMT2 has several biochemical functions, for example, phosphatidylinositol-3,4,5-trisphosphate binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FERMT2 itself. We selected most functions FERMT2 had, and list some proteins which have the same functions with FERMT2. You can find most of the proteins on our site.

    Function Related Protein
    phosphatidylinositol-3,4,5-trisphosphate binding CYTH3,PIRT,ZFYVE16,GAB2,PARD3,RACGAP1,MYO1G,NRGN,ZFYVE1,RS1
    protein binding AF251705,SEPT6,TECPR2,CFI,KRT2,NTM,TLR6,UCP3,DTD2,CFH

    Interacting Protein

    FERMT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FERMT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FERMT2.

    CTNNB1;TCF4;ITGB5

    Resources

    References

    • Tan, CL; Andrews, MR; et al. Kindlin-1 Enhances Axon Growth on Inhibitory Chondroitin Sulfate Proteoglycans and Promotes Sensory Axon Regeneration. JOURNAL OF NEUROSCIENCE 32:7325-7335(2012).
    • Sin, S; Bonin, F; et al. Role of the Focal Adhesion Protein Kindlin-1 in Breast Cancer Growth and Lung Metastasis. JOURNAL OF THE NATIONAL CANCER INSTITUTE 103:1323-1337(2011).

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