FCN3

  • Official Full Name

    ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

  • Overview

    Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.

  • Synonyms

    FCN3;ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen);ficolin-3;FCNH;HAKA1;Collagen/fibrinogen domain containing lectin 3 p35;Collagen/fibrinogen domain containing protein 3;FCN 3;Ficolin (collagen/fibrinogen domain containing) 3;Ficolin 3;H ficolin;Hakata antigen;MGC22543;H-ficolin;OTTHUMP00000006338;OTTHUMP00000006339;collagen/fibrinogen domain-containing protein 3;collagen/fibrinogen domain-containing lectin 3 p35

Recombinant Proteins

  • Human
  • E.coli
  • Mammalian cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
FCN3-12827H Recombinant Human FCN3, GST-tagged E.coli Human GST 20-288a.a.
FCN3-854H Active Recombinant Human FCN3 Protein, His-tagged Mammalian cells Human His Lys22-Arg288
FCN3-1949H Recombinant Human FCN3 protein, His-tagged E.coli Human His Glu34~Met297
FCN3-4004H Recombinant Human FCN3 Protein, GST-tagged Wheat Germ Human GST
FCN3-614HCL Recombinant Human FCN3 cell lysate Human Non
FCN3-2893H Recombinant Human FCN3 protein, His-tagged E.coli Human His 24-299aa
FCN3-2937H Recombinant Human FCN3 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
FCN3-2937H-B Recombinant Human FCN3 Protein Pre-coupled Magnetic Beads HEK293 Human
FCN3-4766HF Recombinant Full Length Human FCN3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 288 amino acids

    Involved Pathway

    FCN3 involved in several pathways and played different roles in them. We selected most pathways FCN3 participated on our site, such as Complement cascade,Creation of C4 and C2 activators,Ficolins bind to repetitive carbohydrate structures on the target cell surface, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Initial triggering of complement C1rb,FCN1,IgG3,CFD,GZMM,HBL3,CRP,BFB,FCN2,MASP2
    Complement cascade GZMM,FCN2,RCA2.1,FCN1,CFHL3,CFD,IGLC2,IGKV1-5,C1rb,HBL3
    Innate Immune System NLRP4E,MB21D1,BAIAP2,TAX1BP1,CLEC4D,CR1,BFB,POLR3H,DEFA6,TNRC5
    Lectin pathway of complement activation FCN1,HBL3,FCN2
    Creation of C4 and C2 activators CRP,FCN2,IGKC,C1rb,FCN1,IGKV1-5,MASP2,HBL3,IgG3,IGLC2
    Ficolins bind to repetitive carbohydrate structures on the target cell surface FCN1,FCN2,MASP2
    Immune System KPNA3,ADAR,PAG1,KIF3C,TNIP2,LTF,MX2,DEFB103A,UNC93B1,NLRP4E

    Protein Function

    FCN3 has several biochemical functions, for example, antigen binding,carbohydrate binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCN3 itself. We selected most functions FCN3 had, and list some proteins which have the same functions with FCN3. You can find most of the proteins on our site.

    Function Related Protein
    carbohydrate binding CLEC4D,GALNTL4,CLEC18B,GALNT13,GALNT4,PKD1L3,KLRA8,SBP,LGALS3L,CD248
    antigen binding IGKC,IGLC2,MHC1UKA,LILRA1,LILRB4,Ighg2a,PPP2R1A,IGJ,KIR2DL3,SLAMF1
    protein binding RIPK2,SNX9,TRAP1,IRF2,ITGB3B,ZNF124,EEF1B2,GAK,DCUN1D5,KIF18A

    Interacting Protein

    FCN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FCN3.

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