FCN1
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Official Full Name
ficolin (collagen/fibrinogen domain containing) 1 -
Overview
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins.However, all these proteins recognize different targets, and are functionally distinct.Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. -
Synonyms
FCN1;ficolin (collagen/fibrinogen domain containing) 1;ficolin-1;FCNM;Collagen/fibrinogen domain containing protein 1;Collagen/fibrinogen domain-containing protein 1;FCN1_HUMAN;Ficolin 1;Ficolin A;Ficolin alpha;Ficolin-A;Ficolin-alpha;M ficolin;M-ficolin;OTTHUMP00000022519;ficolin (collagen/fibrinogen domain-containing) 1
Recombinant Proteins
- Human
- Rhesus macaque
- HEK293
- Mammalian cells
- Wheat Germ
- E.coli
- Human Cell
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Fc
- Myc&DDK
Involved Pathway
FCN1 involved in several pathways and played different roles in them. We selected most pathways FCN1 participated on our site, such as Complement cascade,Creation of C4 and C2 activators,Ficolins bind to repetitive carbohydrate structures on the target cell surface, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lectin pathway of complement activation | FCN3,FCN2,HBL3 |
| Complement cascade | CR1,IGKC,MASP2,RCA2.1,CRP,IGLC2,IgG3,BFB,FCN3,CFHL4 |
| Ficolins bind to repetitive carbohydrate structures on the target cell surface | MASP2,FCN3,FCN2 |
| Creation of C4 and C2 activators | IGKV1-5,FCN3,C1rb,HBL3,FCN2,IGLC2,MASP2,IGKC,CRP,IgG3 |
| Initial triggering of complement | HBL3,MASP2,GZMM,IgG3,FCN2,C1rb,FCN3,BFB,CRP,CFD |
| Immune System | KLC3,DEFB103A,IFI30,CXADR,NCR3LG1,KLHL21,LTN1,PJA2,CLEC6A,ABI1 |
| Innate Immune System | POLR3C,MGC174155,ABI1,DEFB121,POLR3G,POLR3F,NOD1,LGALS3,ART1,LRRFIP1 |
Protein Function
FCN1 has several biochemical functions, for example, G-protein coupled receptor binding,carbohydrate binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCN1 itself. We selected most functions FCN1 had, and list some proteins which have the same functions with FCN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| signaling pattern recognition receptor activity | TRIM5,TLR2,CLEC7A,MARCO,DMBT1,COLEC12 |
| carbohydrate binding | GALNT5,C15orf24,SIGLEC14,KLRA8,GANC,Cd209g,OLR1,KLRC4-KLRK1,FBXO2,CLEC4A |
| protein binding | LMX1B,NFATC1,TRIP13,DCLRE1C,LDHB,MAPK13,ELF3,NHLRC2,FKBP4,CCDC135 |
| sialic acid binding | Siglece,L1CAM,SELE,AGRN,SELP,ADIPOQ,ST8SIA2,ST8SIA3 |
| G-protein coupled receptor binding | STUB1,HSPA1A,GNAV1,AKAP5,PICK1,S1PR2,FYN,GPRC5B,USP20,USP33 |
| metal ion binding | COL9A1,PDE4C,KLF1,CLCA1,UBA2,PRKCDA,HECTD1,FOXP2,ZNF526,ADNP2B |
Interacting Protein
FCN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FCN1.
CRP-1
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