FCGR3
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Official Full Name
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) -
Overview
CD16 is the low affinity IgG Fc receptor III (FcR III) and CD32 is FcR II. CD16/CD32 are expressed on B cells, monocytes/macrophages, NK cells, granulocytes, mast cells, and dendritic cells. The Fc receptors bind antibody-antigen immune complexes and mediate adaptive immune responses. It is useful for blocking non-specific binding of immunoglobulin to the Fc receptors. -
Synonyms
FCGR3A;Fc fragment of IgG, low affinity IIIa, receptor (CD16a);Fc fragment of IgG, low affinity IIIa, receptor for (CD16) , FCG3, FCGR3;low affinity immunoglobulin gamma Fc region receptor III-A;CD16;CD16a;FcgammaRIIIA;CD16a antigen;fc-gamma RIII;Fc-gamma RIIIa;Fc-gamma RIII-alpha;igG Fc receptor III-2;Fc gamma receptor III-A;Fc-gamma receptor IIIb (CD16);neutrophil-specific antigen NA;Fc-gamma receptor III-2 (CD 16);immunoglobulin G Fc receptor III;Fc fragment of IgG, low affinity III, receptor for (CD16);FCG3;CD16A;FCGR3;IGFR3;FCR-10;FCRIII;FCGRIII;FCRIIIA
Recombinant Proteins
- Cynomolgus
- Mouse
- Rhesus macaque
- HEK293
- Mammalian cells
- Human Cell
- E.coli
- His&Avi
- His
- Non
- His&Fc&Avi
- His&SUMO
Involved Pathway
FCGR3 involved in several pathways and played different roles in them. We selected most pathways FCGR3 participated on our site, such as Leishmaniasis,Natural killer cell mediated cytotoxicity,Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCGR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Systemic lupus erythematosus | HIST1H4E,C9,HIST1H4I,H2AFV,HIST1H4K,H2BFWT,H3F3B,HIST1H3H,HIST1H4G,H3F3C |
| Natural killer cell mediated cytotoxicity | RAET1G,IFNA17,IFNAR2,VAV1,PIK3CG,NCR3,RAET1L,TNFSF10,PPP3R2,VAV2 |
| Tuberculosis | ARHGEF12,FCGR1,CYCS,VDR,TRAF6,MAPK1,AKT1,ATP6V0C,PPP3CB,CEBPG |
| Phagosome | HBL4,DYNC2H1,BLB1,ITGB1,BMA2,H2-Q10,HLA-DQA1,HLA-DQA2,HLA-DQB1,CTSSB.1 |
| Leishmaniasis | FCGR2C,STAT1,MAP3K7,ITGAM,HLA-DRA,IL12A,NCF1,HLA-DOB,IL12B,NFKB1 |
| Osteoclast differentiation | FCGR3A,IFNAR2,SIRPA,IFNB1,IL1A,FOSL2,MITF,IFNAR1,LILRB3,MAPK13 |
| Staphylococcus aureus infection | PLG,HLA-DOA,FPR2,GM5077,C4A,Hc,FPR1,HLA-DPA1,FPR3,C1QB |
Protein Function
FCGR3 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by FCGR3 itself. We selected most functions FCGR3 had, and list some proteins which have the same functions with FCGR3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
FCGR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCGR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FCGR3.
Resources
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References
- Eckhardt, CL; Astermark, J; et al. The Fc gamma receptor IIa R131H polymorphism is associated with inhibitor development in severe hemophilia A. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 12:1294-1301(2014).
- Bullich, G; Ballarin, J; et al. HLA-DQA1 and PLA2R1 Polymorphisms and Risk of Idiopathic Membranous Nephropathy. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 9:335-343(2014).
