FBXW4

  • Official Full Name

    F-box and WD repeat domain containing 4

  • Overview

    This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.

  • Synonyms

    FBXW4;F-box and WD repeat domain containing 4;F box and WD 40 domain protein 4 , SHFM3, split hand/foot malformation (ectrodactyly) type 3;F-box/WD repeat-containing protein 4;dactylin;Fbw4;DAC;F box and WD 40 domain containing protein 4;F box and WD 40 domain protein 4;F box and WD repeat domain containing 4;F box/WD repeat containing protein 4;F box/WD repeat protein 4;F-box and WD-40 domain-containing protein 4;FBW 4;FBWD 4;FBWD4;FBXW 4;FBXW4_HUMAN;OTTHUMP00000059175;SHFM 3;SHSF 3;SHSF3;Split hand/foot malformation (ectrodactyly) type;F-box/WD repeat protein 4;F-box and WD-40 domain protein 4;SHFM3

Recombinant Proteins

  • Rhesus macaque
  • Human
  • Mouse
  • Zebrafish
  • Mammalian Cell
  • E.coli
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • His&Fc&Avi
  • His&SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
FBXW4-1671R Recombinant Rhesus monkey FBXW4 Protein, His-tagged Mammalian Cell Rhesus macaque His
FBXW4-30064TH Recombinant Human FBXW4, His-tagged E.coli Human His 65-394 a.a.
FBXW4-3971H Recombinant Human FBXW4 Protein, GST-tagged Wheat Germ Human GST
FBXW4-5778M Recombinant Mouse FBXW4 Protein Mammalian Cell Mouse His
FBXW4-9070Z Recombinant Zebrafish FBXW4 Mammalian Cell Zebrafish His
FBXW4-6284HCL Recombinant Human FBXW4 293 Cell Lysate HEK293 Human Non
FBXW4-1495R Recombinant Rhesus Macaque FBXW4 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
FBXW4-1495R-B Recombinant Rhesus Macaque FBXW4 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
FBXW4-2889H Recombinant Human FBXW4 protein, His-SUMO-tagged E.coli Human His&SUMO 1-412aa
FBXW4-3178M Recombinant Mouse FBXW4 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
FBXW4-3178M-B Recombinant Mouse FBXW4 Protein Pre-coupled Magnetic Beads HEK293 Mouse
FBXW4-4716HF Recombinant Full Length Human FBXW4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 412 amino acids

    Involved Pathway

    FBXW4 involved in several pathways and played different roles in them. We selected most pathways FBXW4 participated on our site, such as Association of TriC/CCT with target proteins during biosynthesis,Chaperonin-mediated protein folding,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXW4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Association of TriC/CCT with target proteins during biosynthesis FBXL5,CCT3,CCT7,CCT6A,CCT4,FKBP9,FBXW2,CCT8,NOP56,KIFC3
    Metabolism of proteins GALNT5,PIGK,TRAPPC4,TIMM22,ST8SIA3,EIF4H,SCFD1,ADAMTS4,GAS6,SFTPC
    Chaperonin-mediated protein folding PFDN1,TUBB4B,CCT8,FBXW5,CCT4,PFDN2,FBXW9,CCT7,FBXL5,PFDN5
    Protein folding ARL2,SERPINA7,NOP56,FKBP9,FBXW9,PFDN1,FBXW5,TBCE,KIFC3,VBP1

    Protein Function

    FBXW4 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXW4 itself. We selected most functions FBXW4 had, and list some proteins which have the same functions with FBXW4. You can find most of the proteins on our site.

    Function Related Protein
    molecular_function DAW1,GJD4,STOML3B,TMEM225,ZNF688,RPRD2A,GM11938,LHFPL5B,GM11570,SPECC1LA

    Interacting Protein

    FBXW4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXW4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXW4.

    SKP1;CUL1;CDC37;ECSIT;RNF32;MAST1;SLX4IP

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