FBXO9
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Official Full Name
F-box protein 9 -
Overview
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5 terminus. -
Synonyms
FBXO9;F-box protein 9;F box only protein 9;F-box only protein 9;FBX9;NY REN 57;F-box protein Fbx9;cross-immune reaction antigen 1;renal carcinoma antigen NY-REN-57;VCIA1;NY-REN-57;dJ341E18.2;KIAA0936;DKFZp434C0118
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
FBXO9 involved in several pathways and played different roles in them. We selected most pathways FBXO9 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
FBXO9 has several biochemical functions, for example, protein binding,ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO9 itself. We selected most functions FBXO9 had, and list some proteins which have the same functions with FBXO9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | HUWE1,CBLB,UBE3A,RNF151,MUL1,UBE2A,MARCH8,FBXO21,FBXL7,RNF187 |
| protein binding | LPAL2,WHSC2,RSRC2,TRIM6,CEP68,METAP2,EPS15L1,FBXO4,ELN,ELK4 |
Interacting Protein
FBXO9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO9 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO9.
HSP90AB1;SKP1;hmsH;pckA
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References
- Lee, KW; Kwak, SH; et al. F-box only protein 9 is required for adipocyte differentiation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 435:239-243(2013).
- Fernandez-Saiz, V; Targosz, BS; et al. SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma. NATURE CELL BIOLOGY 15:72-U164(2013).
