FBXO5
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Official Full Name
F-box protein 5 -
Overview
Fbx5 (also known as F-box protein Fbx5, early mitotic inhibitor (Emi1), and F-box only protein 5) is a 44 kD nuclear protein containing an F-box. Fbx5 inhibits APC by binding to Cdc20 and promotes mitotic entry and cyclin A accumulation. Fbx5 is transcrip -
Synonyms
FBXO5;F-box protein 5;F box only protein 5;F-box only protein 5;EMI1;FBX5;Fbxo31;F-box protein Fbx5;early mitotic inhibitor 1
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FBXO5-1156Z | Recombinant Zebrafish FBXO5 | Mammalian Cell | Zebrafish | His |
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| FBXO5-3957H | Recombinant Human FBXO5 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FBXO5-5759M | Recombinant Mouse FBXO5 Protein | Mammalian Cell | Mouse | His |
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| FBXO5-6290HCL | Recombinant Human FBXO5 293 Cell Lysate | HEK293 | Human | Non |
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| FBXO5-3173M | Recombinant Mouse FBXO5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FBXO5-3173M-B | Recombinant Mouse FBXO5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FBXO5-4680HF | Recombinant Full Length Human FBXO5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 447 amino acids |
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Involved Pathway
FBXO5 involved in several pathways and played different roles in them. We selected most pathways FBXO5 participated on our site, such as Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oocyte meiosis | INSB,CPEB2,PGR,CALM4,CAMK2B1,PPP1CBL,CAMK2G1,CDC16,PPP1CAB,SMC1AL |
Protein Function
FBXO5 has several biochemical functions, for example, metal ion binding,protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO5 itself. We selected most functions FBXO5 had, and list some proteins which have the same functions with FBXO5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | JAK2,EEF2,SPRED1,KIF14,SREBF1,SKI,FER,PKD1,DNM1,XBP1 |
| protein binding | INO80,ZNF792,CAMK1,RGS14,ETL4,MEMO1,TUBGCP2,FGF19,BCL7B,C17orf62 |
| metal ion binding | SAR1B,ZNF148,CRYABA,ESCO1,ZFP827,PRSS37,LMO4A,ADAMTS7,ZFP511,ZBTB49 |
Interacting Protein
FBXO5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO5 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO5.
EVI5;CDC27;Cdc23;Cdc16;Cdc26;PLK1;TPM3;SKP1;ANAPC15
Resources
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References
- Haenold, R; Weih, F; et al. NF-kappa B controls axonal regeneration and degeneration through cell-specific balance of RelA and p50 in the adult CNS. JOURNAL OF CELL SCIENCE 127:3052-3065(2014).
- Shoji, S; Muto, Y; et al. The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation. FEBS OPEN BIO 4:689-703(2014).
