FBXO4
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Official Full Name
F-box protein 4 -
Overview
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. -
Synonyms
FBXO4;F-box protein 4;F box only protein 4;F-box only protein 4;FBX4;DKFZp547N213;F box protein 4;F box protein Fbx4;FBXO 4;FLJ10141;F-box protein Fbx4
Recombinant Proteins
- Human
- Mouse
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- E.coli
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FBXO4-3945H | Recombinant Human FBXO4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FBXO4-5750M | Recombinant Mouse FBXO4 Protein | Mammalian Cell | Mouse | His |
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| FBXO4-6295HCL | Recombinant Human FBXO4 293 Cell Lysate | HEK293 | Human | Non |
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| FBXO4-1791H | Recombinant Human FBXO4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Fbxo4-290M | Recombinant Mouse Fbxo4 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| FBXO4-3166M | Recombinant Mouse FBXO4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FBXO4-3166M-B | Recombinant Mouse FBXO4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FBXO4-4676HF | Recombinant Full Length Human FBXO4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 387 amino acids |
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| FBXO4-5968H | Recombinant Human FBXO4 protein, His-tagged | E.coli | Human | His | 1-387aa |
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Involved Pathway
FBXO4 involved in several pathways and played different roles in them. We selected most pathways FBXO4 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | TCEB1B,CDC26,UBE2J1,BTRC,FBXW11B,CDC27,SKP2,PIAS4A,PRP19,ANAPC2 |
Protein Function
FBXO4 has several biochemical functions, for example, protein binding,protein homodimerization activity,ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO4 itself. We selected most functions FBXO4 had, and list some proteins which have the same functions with FBXO4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | C1QB,AIMP1,TCF3B,ZFP423,VOX,ADSSL1,RNF17,TRIM37,BLOC1S6,XPA |
| protein binding | ARAF,DNAI1,STK39,SMU1,NDUFAF3,ATM,CYS1,CIT,TRAIP,IL17F |
| ubiquitin-protein transferase activity | UBE2T,RNF5,TRAF7,ITCHA,FBXO40.1,UBE2G2,MARCH1,TRIP12,RNF182,UBE2D2 |
Interacting Protein
FBXO4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO4.
CUL1;YWHAE;SKP1;Ywhae;SKP1;22046569;HSP90AB1;Ywhae;NEDD8
Resources
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References
- Lee, EK; Lian, Z; et al. The FBXO4 Tumor Suppressor Functions as a Barrier to Braf(V600E)-Dependent Metastatic Melanoma. MOLECULAR AND CELLULAR BIOLOGY 33:4422-4433(2013).
- Zhou, F; Yan, H; et al. FBXW10 is negatively regulated in transcription and expression level by protein O-GlcNAcylation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 438:427-432(2013).
