FBXO25
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Official Full Name
F-box protein 25 -
Overview
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
FBXO25;F-box protein 25;F box only protein 25;F-box only protein 25;FBX25;F-box protein Fbx25;MGC20256;MGC51975
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Rat
- Human
- Cynomolgus
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
FBXO25 involved in several pathways and played different roles in them. We selected most pathways FBXO25 participated on our site, such as FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | SGK2A,GRM1,PTENA,CCND2A,FOXG1,KRAS,SGK3,GABARAP,TGFB1,PIK3CG |
Protein Function
FBXO25 has several biochemical functions, for example, actin binding,protein binding,ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO25 itself. We selected most functions FBXO25 had, and list some proteins which have the same functions with FBXO25. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | FBXO2,FBXO22,RNF10,ARIH2,FBXO40.1,RFWD3,MARCH5L,RNF187,TRIM33,LNX2B |
| actin binding | GCSAM,MYHZ1.1,DSTN,ACTR3B,GC,SHROOM3,VASPA,FMN1,HCLS1,CNN3B |
| protein binding | USP9X,GTF3C4,MECP2,H2-KE2,USP14,HSF1,SPCS1,TMEM203,MSH6,RNF2 |
Interacting Protein
FBXO25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO25 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO25.
CUL1;SKP1;ACTB;b4dyc6_human;HSP90AA1;HSP90AB1;FKBP5;HSP90AB1;PPP5C;ORC4;EP300;CAND1
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